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Toxicological stress indicators in human red blood cells changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress /Evelo, Christoffel Theodorus Anthonius. January 1995 (has links)
Proefschrift Rijksuniversiteit Limburg Maastricht. / Met lit. opg. - Met bibliogr. - Met een samenvatting in het Nederlands.
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Évaluation de l'activité inhibitrice de carbamates aromatiques sur la glutathion réductase /Maalaoui, Noura. January 1997 (has links)
Thèse (M.Sc.) -- Université Laval, 1997. / Bibliogr.: f. [82]-88. Publ. aussi en version électronique.
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Nouveaux modèles pour l'étude du rôle de la Glutathion peroxydase dans l'activation des Lipoxygénases /Moisset, Pierre-Alain. January 1997 (has links)
Thèse (M.Sc.) -- Université Laval, 1997. / Bibliogr.: f. 69-79. Publ. aussi en version électronique.
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Effect of vitamin E on glutathione-dependent enzymesHaaften, Rachel I.M. van. January 2003 (has links)
Proefschrift Universiteit Maastricht. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.
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Vliv taurinu na biochemické ukazatele v orgánech laboratorních potkanůMrázková, Martina January 2016 (has links)
The aim of this dissertation was to valorize the effect of various levels of taurine on the antioxidant status in rats body, monitor serum taurine and individual aminoacids in selectedorgans. This dissertation valorize the influence of taurine in the rats liver and brain after its application into feed mixtures. The effect of taurine was monitored on the ratio of GSH / GSSG,concentration of metallothionein and taurine. To this experiment were used 48 Wistar male rats, which were divided into eight groups (n = 6). During four weeks feed mixtures were given to these rats enriched with taurin eat a dose of 0, 1000, 1500, 2000 2500, 3000, 3500 and 4000 mg / kg / diet. Animals accepted diet and drinking water ad libitum. Average consumption of feed mixtures were 35 grams per day. Application taurine in creased concentration of taurine in the organism, which has an positive effect on antioxidant mechanisms of the organism. In deed we can not confirm that the addition of taurine in to the diet increases the concentrations of metallothionein and glutathione in the organism. In the brain was found increasing ratio of GSH / GSSG and reduced concentration of metallothionein. The other way around in the liver was reduction ratio of GSH / GSSG and increasing concentration of metallothionein.
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Vliv vybraných těžkých kovů na různé genotypy lnu setéhoČížková, Martina January 2009 (has links)
No description available.
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Analýza metalothioneinu pomocí imunologických a elektrochemických technikBláhová, Pavlína January 2007 (has links)
No description available.
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Studium interakce těžkých kovů s glutathionem. Význam pro in vitro kultivace rostlinBaloun, Jiří January 2008 (has links)
No description available.
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The isomerization of △⁵–androstene-3,17-dione by hGST A3-3: the pursuit of catalytic perfection in proton abstraction reactions of 3-ketosteroidsDaka, Jonathan Lembelani 07 May 2015 (has links)
A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of requirements for the degree of Master of Science. Johannesburg, 2014. / The seemingly simple proton abstraction reactions underpin many chemical
transformations including isomerization reactions and are thus of immense biological
significance. Despite the energetic cost, enzyme-catalyzed proton abstraction reactions
show remarkable rate enhancements. The pathways leading to these accelerated rates are
numerous and on occasion partly enigmatic. The isomerization of the steroid, Δ5-
androstene-3,17-dione by the human glutathione transferase A3-3 in mammals was
investigated to gain insight into the mechanism. Particular emphasis was placed on the
nature of the transition state, the intermediate suspected of aiding this process and the
hydrogen bonds postulated to be the stabilizing forces of these transient species. Kinetics
studies on Δ5-androstene-17-one, a substrate that is incapable of forming hydrogen bonds
reveal that such stabilizing forces are not a requirement to explain the observed rate
enhancements. The UV-Vis detection of the intermediate places this specie in the catalytic
pathway while fluorescence spectroscopy is used to obtain the binding constant of the
intermediate analogue equilenin. Analysis of the kinetics data in terms of the Marcus
formalism indicates that the human glutathione transferase A3-3 lowers the intrinsic
kinetic barrier by 3 kcal/mole. The results lead to the conclusion that this reaction proceeds
through an enforced concerted mechanism in which the barrier to product formation is
kinetically insignificant.
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Synthèse d'analogues photoactivables du glutathion pour l'étude du système cellulaire du glutathion /Bernardi, Dan Dicko, Amadou. January 2008 (has links) (PDF)
Reproduction de : Thèse de doctorat : Chimie moléculaire : Metz : 2005. / Titre provenant de l'écran-titre. Notes bibliographiques.
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