Glyphosate-resistant (GR) Italian ryegrass has been documented in many different countries around the world and has now become a major problem in row crop production areas of Mississippi. Field experiments were conducted from 2006 to 2008 in the Mississippi Delta to evaluate various herbicide and tillage treatment programs for its control. style='mso-spacerun:yes'> Highest level of control and reduction of GR Italian ryegrass biomass was observed with mechanically incorporated as well as surface applied residual herbicides in the fall of the year. style='mso-spacerun:yes'> Control of GR Italian ryegrass was 86-95% with surface applications of clomazone at 0.56, 0.84, and 1.12 kg ai/ha, s-metolachlor at 1.79 kg class=SpellE>ai/ha and KIH-485 at 0.16 kg ai/ha 171 days after emergence. Using a systems approach, preplant incorporated (PPI) class=SpellE>clomazone and/or s- class=SpellE>metolachlor followed by preemergence (PRE) application of paraquat + linuron+ non-ionic surfactant was also found to control and reduce biomass of GR Italian ryegrass.