Groupwise non-rigid image registration is a powerful tool to automatically establish correspondences across sets of images. Such correspondences are widely used for constructing statistical models of shape and appearance. As existing techniques usually treat registration as an optimisation problem, a good initialisation is required. Although the standard initialisation---affine transformation---generally works well, it is often inadequate when registering images of complex structures. In this thesis we present a sophisticated system that uses the sparse matches of one or more parts+geometry models as the initialisation. We show that both the model/s and its/their matches can be automatically obtained, and that the matches are able to effectively initialise a groupwise non-rigid registration algorithm, leading to accurate dense correspondences. We also show that the dense mesh models constructed during the groupwise registration process can be used to accurately annotate new images. We demonstrate the efficacy of the proposed system on three datasets of increasing difficulty, and report on a detailed quantitative evaluation of its performance.

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This study develops a panel data analysis over 27 transition and post transition economies for the period 2003-2010. Its intent is to investigate empirically the true effect of seven variables into foreign flows and takes later on the advantage of observed findings to conduct a comparative analysis between Kosovo and regional countries such: Albania, Bosnia and Herzegovina, Macedonia, Montenegro and Serbia. As the breakdown period (2008-2010) was included in the data set used to modelling the behaviour of FDI, both Chow test and the time dummies technique suggest the presence of structural break. Ultimately, empirical results show that FDI is positively related with one year lagged effect of real GDP growth, trade openness, labour force, low level of wages proxied by remittances, real interest rate and the low level of corruption. Besides, the corporate income tax is found to be significant and inversely related with foreign flows. The comparative analysis referring the growth rate of real GDP shows that Kosovo has the most stable macroeconomic environment in the region, but still it is continuously confronted by the high deficit of trade balance and high rate of unemployment. Appart, the key obstacle that has abolished efforts for foreign investment attraction is found to be the trade blockade of...

Calculations of reactor parameters of interest (such as neutron multiplication factors, decay heat, reaction rates, etc.), are often based on models which are dependent on groupwise neutron cross sections. The uncertainties associated with these neutron cross sections are propagated to the final result of the calculated reactor parameters. There is a need to characterize this uncertainty and to be able to apportion the uncertainty in a calculated reactor parameter to the different sources of uncertainty in the groupwise neutron cross sections, this procedure is known as sensitivity analysis. The focus of this study is the application of a modified global sensitivity analysis technique to calculations of reactor parameters that are dependent on groupwise neutron cross–sections. Sensitivity analysis can help in identifying the important neutron cross sections for a particular model, and also helps in establishing best–estimate optimized nuclear reactor physics models with reduced uncertainties. In this study, our approach to sensitivity analysis will be similar to the variance–based global sensitivity analysis technique, which is robust, has a wide range of applicability and provides accurate sensitivity information for most models. However, this technique requires input variables to be mutually independent. A modification to this technique, that allows one to deal with input variables that are block–wise correlated and normally distributed, is presented. The implementation of the modified technique involves the calculation of multi–dimensional integrals, which can be prohibitively expensive to compute. Numerical techniques specifically suited to the evaluation of multidimensional integrals namely Monte Carlo, quasi–Monte Carlo and sparse grids methods are used, and their efficiency is compared. The modified technique is illustrated and tested on a two–group cross–section dependent problem. In all the cases considered, the results obtained with sparse grids achieved much better accuracy, while using a significantly smaller number of samples. / Thesis (M.Sc. Engineering Sciences (Nuclear Engineering))--North-West University, Potchefstroom Campus, 2011.

Calculations of reactor parameters of interest (such as neutron multiplication factors, decay heat, reaction rates, etc.), are often based on models which are dependent on groupwise neutron cross sections. The uncertainties associated with these neutron cross sections are propagated to the final result of the calculated reactor parameters. There is a need to characterize this uncertainty and to be able to apportion the uncertainty in a calculated reactor parameter to the different sources of uncertainty in the groupwise neutron cross sections, this procedure is known as sensitivity analysis. The focus of this study is the application of a modified global sensitivity analysis technique to calculations of reactor parameters that are dependent on groupwise neutron cross–sections. Sensitivity analysis can help in identifying the important neutron cross sections for a particular model, and also helps in establishing best–estimate optimized nuclear reactor physics models with reduced uncertainties. In this study, our approach to sensitivity analysis will be similar to the variance–based global sensitivity analysis technique, which is robust, has a wide range of applicability and provides accurate sensitivity information for most models. However, this technique requires input variables to be mutually independent. A modification to this technique, that allows one to deal with input variables that are block–wise correlated and normally distributed, is presented. The implementation of the modified technique involves the calculation of multi–dimensional integrals, which can be prohibitively expensive to compute. Numerical techniques specifically suited to the evaluation of multidimensional integrals namely Monte Carlo, quasi–Monte Carlo and sparse grids methods are used, and their efficiency is compared. The modified technique is illustrated and tested on a two–group cross–section dependent problem. In all the cases considered, the results obtained with sparse grids achieved much better accuracy, while using a significantly smaller number of samples. / Thesis (M.Sc. Engineering Sciences (Nuclear Engineering))--North-West University, Potchefstroom Campus, 2011.

Registration of a group of images generally only gives a pointwise, dense correspondence defined over the whole image plane or volume, without having any specific description of any common structure that exists in every image. Furthermore, identifying tissue classes and structures that are significant across the group is often required for analysis, as well as the correspondence. The overall aim is instead to perform registration, segmentation, and modelling simultaneously, so that the registration can assist the segmentation, and vice versa. However, structural information does play a role in conventional registration, in that if the registration is successful, it would be expected structures to be aligned to some extent. Hence, we perform initial experiments to investigate whether there is explicit structural information present in the shape of the registration objective function about the optimum. We perturbed one image locally with a diffeomorphism, and found interesting structure in the shape of the quality of fit function. Then, we proceed to add explicit structural information into registration framework, using various types of structural information derived from the original intensity images. For the case of MR brain images, we augment each intensity image with its own set of tissue fraction images, plus intensity gradient images, which form an image ensemble for each example. Then, we perform groupwise registration by using these ensembles of images. We apply the method to four different real-world datasets, for which ground-truth annotation is available. It is shown that the method can give a greater than 25% improvement on the three difficult datasets, when compared to using intensity-based registration alone. On the easier dataset, it improves upon intensity-based registration, and achieves results comparable with the previous method.

L'analyse quantitative de la perfusion myocardique, i.e. l'estimation d'indices de perfusion segmentaires puis leur confrontation à des valeurs normatives, constitue un enjeu majeur pour le dépistage, le traitement et le suivi des cardiomyopathies ischémiques --parmi les premières causes de mortalité dans les pays occidentaux. Dans la dernière décennie, l'imagerie par résonance magnétique de perfusion (IRM-p) est la modalité privilégiée pour l'exploration dynamique non-invasive de la perfusion cardiaque. L'IRM-p consiste à acquérir des séries temporelles d'images cardiaques en incidence petit-axe et à plusieurs niveaux de coupe le long du grand axe du cœur durant le transit d'un agent de contraste vasculaire dans les cavités et le muscle cardiaques. Les examens IRM-p résultants présentent de fortes variations non linéaires de contraste et des artefacts de mouvements cardio-respiratoires. Dans ces conditions, l'analyse quantitative de la perfusion myocardique est confrontée aux problèmes complexes de recalage et de segmentation de structures cardiaques non rigides dans des examens IRM-p. Cette thèse se propose d'automatiser l’analyse quantitative de la perfusion du myocarde en développant un outil d'aide au diagnostic non supervisé dédié à l'IRM de perfusion cardiaque de premier passage, comprenant quatre étapes de traitement : -1.sélection automatique d'une région d'intérêt centrée sur le cœur; -2.compensation non rigide des mouvements cardio-respiratoires sur l'intégralité de l'examen traité; -3.segmentation des contours cardiaques; -4.quantification de la perfusion myocardique. Les réponses que nous apportons aux différents défis identifiés dans chaque étape s'articulent autour d'une idée commune : exploiter l'information liée à la cinématique de transit de l'agent de contraste dans les tissus pour discriminer les structures anatomiques et guider le processus de recalage des données. Ce dernier constitue le travail central de cette thèse. Les méthodes de recalage non rigide d'images fondées sur l'optimisation de mesures d'information constituent une référence en imagerie médicale. Leur cadre d'application usuel est l'alignement de paires d'images par appariement statistique de distributions de luminance, manipulées via leurs densités de probabilité marginales et conjointes, estimées par des méthodes à noyaux. Efficaces pour des densités jointes présentant des classes individualisées ou réductibles à des mélanges simples, ces approches atteignent leurs limites pour des mélanges non-linéaires où la luminance au pixel s’avère être un attribut trop frustre pour permettre une décision statistique discriminante, et pour des données mono-modal avec variations non linéaires et multi-modal. Cette thèse introduit un modèle mathématique de recalage informationnel multi-attributs/multi-vues générique répondant aux défis identifiés: (i) alignement simultané de l'intégralité de l'examen IRM-p analysé par usage d'un atlas, naturel ou synthétique, dans lequel le cœur est immobile et en utilisant les courbes de rehaussement au pixel comme ensemble dense de primitives; et (ii) capacité à intégrer des primitives image composites, spatiales ou spatio-temporelles, de grande dimension. Ce modèle, disponible dans le cadre classique de Shannon et dans le cadre généralisé d'Ali-Silvey, est fondé sur de nouveaux estimateurs géométriques de type k plus proches voisins des mesures d'information, consistants en dimension arbitraire. Nous étudions leur optimisation variationnelle en dérivant des expressions analytiques de leurs gradients sur des espaces de transformations spatiales régulières de dimension finie et infinie, et en proposant des schémas numériques et algorithmiques de descente en gradient efficace. Ce modèle de portée générale est ensuite instancié au cadre médical ciblé, et ses performances, notamment en terme de précision et de robustesse, sont évaluées dans le cadre d'un protocole expérimental tant qualitatif que quantitatif / Quantitative assessment of moycardium perfusion, i.e. computation of perfusion parameters which are then confronted to normative values, is a key issue for the diagnosis, therapy planning and monitoring of ischemic cardiomyopathies --the leading cause of death in Western countries. Within the last decade, perfusion magnetic resonance imaging (p-MRI) has emerged as a reference modality for reliably assessing myocardial perfusion in a noninvasive and accurate way. In p-MRI acquisitions, short-axis image sequences are captured at multiple slice levels along the long-axis of the heart during the transit of a vascular contrast agent through the cardiac chambers and muscle. Resulting p-MRI exams exhibit high nonlinear contrast variations and complex cardio-thoracic motions. Perfusion assessment is then faced with the complex problems of non rigid registration and segmentation of cardiac structures in p-MRI exams. The objective of this thesis is enabling an automated quantitative computer-aided diagnosis tool for first pass cardiac perfusion MRI, comprising four processing steps: -1.automated cardiac region of interest extraction; -2.non rigid registration of cardio-thoracic motions throughout the whole sequence; -3.cardiac boundaries segmentation; -4.quantification of myocardial perfusion. The answers we give to the various challenges identified in each step are based on a common idea: investigating information related to the kinematics of contrast agent transit in the tissues for discriminating the anatomical structures and driving the alignment process. This latter is the main work of this thesis. Non rigid image registration methods based on the optimization of information measures provide versatile solutions for robustly aligning medical data. Their usual application setting is the alignment of image pairs by statistically matching luminance distributions, handled using marginal and joint probability densities estimated via kernel techniques. Though efficient for joint densities exhibiting well-separated clusters or reducible to simple mixtures, these approaches reach their limits for nonlinear mixtures where pixelwise luminance appears to be a too coarse feature for allowing unambiguous statistical decisions, and for mono-modal with nonlinear variations and multi-modal data. This thesis presents a unified mathematical model for the information-theoretic multi-feature/multi-view non rigid registration, addressing the identified challenges : (i) simultaneous registration of the whole p-MRI exam, using a natural or synthetic atlas generated as a motion-free exam depicting the transit of the vascular contrast agent through cardiac structures and using local contrast enhancement curves as a feature set; (ii) can be easily generalized to richer feature spaces combining radiometric and geometric information. The resulting model is based on novel consistent k-nearest neighbors estimators of information measures in high dimension, for both classical Shannon and generalized Ali-Silvey frameworks. We study their variational optimization by deriving under closed-form their gradient flows over finite and infinite dimensional smooth transform spaces, and by proposing computationally efficient gradient descent schemas. The resulting generic theoretical framework is applied to the groupwise alignment of cardiac p-MRI exams, and its performances, in terms of accuracy and robustness, are evaluated in an experimental qualitative and quantitative protocol