Evidenced based nursing seeks to integrate new knowledge from current research into practice. The use of clinical practice guidelines is one method of accomplishing this. The purpose of this study was to assess the effect of differing clinical practice guideline representation formats on the quality of nursing care plans and on the experiences of nurses. To accomplish this, an experimental study taking place in a laboratory setting was executed. BC Cancer Agency nurses volunteered as the participants. The nurses were given case scenarios and asked to generate nursing care plans with the assistance of clinical practice guidelines. The clinical practice guidelines were presented in two formats: Portable Document Format (PDF) and Web Based Interactive (WBI). The quality of the care plans was rated using a validated evaluation tool. Participants were asked to ‘think-aloud’ during the care planning process and their experiences were recorded, transcribed, and analyzed through a cognitive task analysis. This study revealed advantages and disadvantages to both formats and provided insight into nurses' experiences. This study also showed no statistically significant difference in the quality of care plan documentation, regardless of clinical practice guideline format. This study highlights the importance of evaluating health informatics projects in healthcare settings to ensure positive outcomes in measures of user experience and measures of documentation quality. / Graduate / 0569 / 0758 / 0984 / csimad@gmail.com