Thesis (M. Phil.)--University of Hong Kong, 1983.

published_or_final_version / Anatomy / Master / Master of Philosophy

No description available.

Typescript. / Bibliography: leaves 158-169. / Photocopy. / Microfilm. / xviii, 169 leaves, bound ill. 29 cm

Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / In human populations, perturbed growth in early life and ageing have been identified as risk factors for the development of Insulin resistance syndrome (IRS). The consequences of restricted prenatal growth on postnatal function have been investigated using numerous experimental models of intrauterine growth retardation, mainly in the rat. These studies have shown that some, but not all, aspects of postnatal function that are programmed in humans are also programmed in the rat. This study was designed to determine whether IRS develops with increasing age in the guinea pig as it does in the human and whether the development of the syndrome is more pronounced in aged offspring which have undergone spontaneous fetal growth restriction and accelerated growth in the neonatal period. It appeared that the guinea pig is a suitable animal model of ageing, displaying many of the metabolic, cardiovascular and anthropometric changes seen in humans. Furthermore, the effects of perturbed prenatal and early postnatal growth on the development of IRS in the aged guinea pig exhibit a sexually dimorphic pattern. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1297545 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2007

Contact Lens Acute Red Eye (CLARE) and Infiltrative Keratitis (IK) are inflammatory responses of the eye associated with extended wear of soft contact lenses. Bacterial colonization of contact lenses with Gram-negative bacteria such as Pseudomonas aeruginosa is an important risk factor for the development of these adverse responses. Strategies that control the bacterial colonization of contact lenses may help prevent the occurrence of adverse responses. This thesis aimed to develop an animal model of CLARE/IK to test this hypothesis and to test the effectiveness of contact lenses containing antimicrobial compounds, namely silver and furanone compounds, in controlling corneal inflammation caused by Pseudomonas aeruginosa. A guinea pig model of contact lens wear was developed for the study and it was observed that the ocular responses to contact lens wear in the guinea pig were similar to those seen in human eyes wearing contact lenses. Also, three different models for CLARE/IK were developed and tested in the guinea pig eye. The pathological features of CLARE/IK in the guinea pig were virtually identical to those observed in human eyes. Bacterial contamination of contact lenses was confirmed to be a major risk factor for the development of CLARE/IK. Contact lenses containing nano-particles of silver demonstrated very good antibacterial activity against Pseudomonas aeruginosa in-vitro. The silver lenses were able to control the development of CLARE/IK responses in one of the models for CLARE/IK. Silver lenses might be most effective if used to prevent the establishment of a biofilm of bacteria on a lens such as might occur during storage in a contact lens case. Contact lenses were coated with different concentrations of the furanone compounds by physical adsorption and demonstrated good antibacterial activity at higher concentrations. However these concentrations were cytotoxic in-vitro and lower concentrations of furanones did not possess adequate antibacterial activity to control CLARE/IK responses in-vivo. This thesis has successfully demonstrated that guinea pigs can be used to test the effects of extended wear of contact lenses and developed models to test the pathogenesis of adverse responses such as CLARE/IK. The CLARE/IK models developed could be used to further our understanding of the pathogenesis of these inflammatory conditions and explore the activity of other antimicrobials.

Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / In human populations, perturbed growth in early life and ageing have been identified as risk factors for the development of Insulin resistance syndrome (IRS). The consequences of restricted prenatal growth on postnatal function have been investigated using numerous experimental models of intrauterine growth retardation, mainly in the rat. These studies have shown that some, but not all, aspects of postnatal function that are programmed in humans are also programmed in the rat. This study was designed to determine whether IRS develops with increasing age in the guinea pig as it does in the human and whether the development of the syndrome is more pronounced in aged offspring which have undergone spontaneous fetal growth restriction and accelerated growth in the neonatal period. It appeared that the guinea pig is a suitable animal model of ageing, displaying many of the metabolic, cardiovascular and anthropometric changes seen in humans. Furthermore, the effects of perturbed prenatal and early postnatal growth on the development of IRS in the aged guinea pig exhibit a sexually dimorphic pattern. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1297545 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2007

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 4 uppsatser.

Thesis (M.Phil.)--University of Hong Kong, 1983. / Also available in print.

Tesis de grado presentada como requisito para obtener el titulo de Ingeniero Agroindustrial, Universidad Técnica del Norte, Facultad de Ingenieria en Ciencias Agropocuarias y Ambientales. / Abstract in Spanish and English.