NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"hematology (drugs anda medicine)"" "subject:"hematology (drugs ando medicine)""

1

Burkitt Lymphoma: Interpreting FISH Testing for Gene Rearrangements

Sharma, Purva, Singal, Sakshi, Costello, Patrick, Krishnan, Koyamangalath 08 February 2022 (has links)
Burkitt lymphoma is a highly aggressive B cell non-Hodgkin's lymphoma characterised by translocation of gene on chromosome 8. This translocation is usually detected by fluorescent in-situ hybridisation (FISH) studies as part of routine diagnostic work-up and prognostication. FISH testing is commonly done with the break-apart probe (BAP). This case illustrates how this testing can be falsely negative. This patient is a young male diagnosed with Stage I low-risk Burkitt with FISH negative for translocation initially on BAP testing. Additional testing with dual FISH probe detected translocation. FISH testing using BAPs alone may be falsely negative for translocations creating a diagnostic challenge and compromising the treatment approach and assessment of prognosis.
carcinogenesis
haematology (drugs and medicines)
pathology
Burkitt lymphoma (diagnosis
genetics)
gene rearrangement
genes
Myc (genetics)
humans
in situ hybridization
fluorescence
male
translocation
genetic
Internal Medicine

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