By examining halokinetics and channel evolution in a deep-water system, we investigate how submarine channel morphology is affected by changing seascape linked to diapirism. The study area is located in Mississippi Canyon, Gulf of Mexico (GOM), situated directly off the continental slope in a prominent salt dome region. Interactions of salt domes with submarine channels in the GOM are poorly documented. Utilizing 3D seismic data and seismic geomorphology techniques, a long-lived Plio-Pleistocene submarine channel system has been investigated to develop a relationship between variable phases of salt movement and plan-form morphology of preserved channels. We suggest that halokinetics acts as a driver for topographic-channel evolution in the study area. We show how submarine channel morphology can be directly controlled by halokinetics, where salt movement can act as a structural control on both location and morphology of meandering channel complexes. Channels are able to move towards an equilibrium state only when holokinetics decreases.