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Thesis (MEng) - Industrial Research Institute Swinburne, Swinburne University of Technology, 2003. / Thesis submitted for the degree of Master of Engineering by Research, Industrial Research Institute Swinburne, Swinburne University of Technology, 2003. Typescript. Includes bibliographical references (p. 159-169).

Thesis (M.S.)--University of Wisconsin--Madison, 1967. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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The durability of a polymer trileaflet valve is dependent on leaflet stress concentrations, so valve designs that reduce stress can, hypothetically, increase durability. Design aspects that are believed to contribute to reduced leaflet stress include stent flexibility, parabolic coaptation curvature, and leaflet anisotropy. With this in mind, the purpose of this investigation was to elucidate what specific combinations of these parameters promote optimal acute and long-term valve function. A combination of four stent designs, seven leaflet reinforcement materials, and three coaptation geometries were evaluated through a combination of experimentation and modeling. Static tensile and Poisson’s ratio tests and dynamic tensile fatigue testing were used to evaluate the individual leaflet components; and hydrodynamic testing and accelerated valve fatigue was used to assess complete valve prototypes. The two most successful designs included a 0.40 mm thick knit-reinforced valve with a fatigue life of 10.35 years, and a 0.20 mm thick knit-reinforced valve with a 28.9 mmHg decrease in pressure drop over the former. A finite element model was incorporated to verify the impact of the above-mentioned parameters on leaflet stress concentrations. Leaflet anisotropy had a large impact on stress concentrations, and matching the circumferential modulus to that of the natural valve showed the greatest benefit. Varying the radial modulus had minimal impact. Varying coaptation geometry had no impact, but stent flexibility did have a marked effect on the stress at the top of the commissure, where a completely rigid stent resulted in a higher peak stress than a flexible stent (E = 385 MPa). In conclusion, stent flexibility and leaflet anisotropy do effect stress concentrations in the SIBS trileaflet valve, but coaptation geometry does not. Regions of high stress concentrations were linked to failure locations in vitro, so a fatigue prediction model was developed from the S/N curves generated during dynamic tensile testing of the 0.20 mm knit-reinforced leaflets. Failure was predicted at approximately 400 million cycles (10 years) at the top of the commissure. In vitro fatigue of this valve showed failure initiation after approximately 167 million cycles (4.18 years), but it was related to a design defect that is subsequently being changed.

One of the major achievements in cardiac surgery over the past 30 years has been the ability to replace severely diseased heart valves with prosthetic ones. The option of using prosthetic heart valves for the treatment of valvular diseases has improved and prolonged many lives. This is reflected in around 120,000 heart valve replacement operations carried out every year in North America alone to correct the cardiovascular problems of stenosis, insufficiency, regurgitation, etc. The development of artificial heart valves depends on reliable knowledge of the hemodynamic performance and physiology of the cardiovascular system in addition to a sound understanding, at the fundamental level, of the associated fluid mechanics. It is evident from the literature review that noninvasive measurements in a confined area of complex transient geometry, providing critical information relating to valve performance, are indeed scarce. This thesis presents results of an extensive test program aimed at measuring turbulence stresses, steady and transient velocity profiles and their decay downstream of the mitral valve. Three mechanical tilting disc-type heart valves (Björk-Shiley convexo- concave, Björk-Shiley monostrut, and Bicer-Val) and two biological tissue valves (Hancock II and Carpentier-Edwards supraannular) are studied. The investigation was carried out using a sophisticated and versatile cardiac simulator in conjunction with a highly sensitive, noninvasive, two-component three-beam laser doppler anemometer system. The study covers both the steady (valve fully open) and pulsatile (resting heart rate) flow conditions. The continuous monitoring of the parametric time histories revealed useful details of the complex flow as well as helped establish location and timing of the peak parameter values. In addition, orientation experiments are conducted on the mechanical valves in an attempt to reduce stresses by altering the position of the major orifice. The experiments suggest correlation between high stresses and orientation. Based on the the data, the following general conclusions can be made: (i) Hemodynamic test results should be presented in nondimensional form to render them independent of test facilities, flow velocities, size of models, etc. This would facilitate comparison of results by different investigators, using different facilities and test conditions. (ii) The valves tested showed very disturbed flow fields which generated high turbulent stresses presenting a possibility of thromboembolism and, perhaps, haemolysis. (iii) Implantation orientation of the valve significantly affect the mechanical prostheses flow field. The single vortex formation in the posterior orientation results in a reduction in stresses compared to the anterior configuration. (iv) The present results together with the earlier information on pressure drop and regurgitation provide a comprehensive and organized picture of the valve performance. (v) The information is fundamental to the improvement in valve design, and development of guidelines for test methodology and acceptable performance criteria for marketing of the valves. / Applied Science, Faculty of / Mechanical Engineering, Department of / Graduate

Left ventricular flows in the human heart are very complex and in the presence of a diseased condition, such as unhealthy or prosthetic heart valves, the complexity of the flow is further increased. The intricacy of the heart geometry combined with the pulsatile character of the flow, the interaction of high-speed jets with the flexible walls, and the unsteady motion of the heart valve leaflets generate inherently complicated flow fields. It is therefore essential that we study and understand the complex cardiac energetics and physics of blood flow in both healthy and diseased hearts. Although artificial heart valves, mechanical and biological, have evolved to a level of universal acceptance, they have never reached a level of performance comparable to that of the natural valves of the heart. Many of the problems are directly related to the fluid mechanics. Considering that mechanical heart valves (MHV) are more commonly implanted because of their durability, it is imperative to better understand their hemodynamic behavior. Yet to date, no study has documented in depth the complex hemodynamic characteristics of left ventricular flows and assessed the intricate structures that are generated in the left ventricle (LV) due to vortex formation (roll-up of shear layers shed past the valve leaflets), turbulence characteristics, and energetics. The flow through pivoted leaflets of MHVs induces a combination of flow characteristics that are dependent on the specific valve design and orientation. The aim of the present study is to provide new insight into the spatio-temporal dynamics of the flow distal to a mitral MHV by employing a state-of-the-art, high resolution, flow diagnostic method, Time Resolved Digital Particle Image Velocimetry (TRDPIV) in a flexible, transparent LV documenting the evolution of eddies and turbulence during a complete period of the heart cycle. The broad impact of the proposed research extends beyond the hemodynamics of heart valve prosthesis. The research herein will enable the development of a tool for application in all cardiac energetic studies (unhealthy valves, tissue engineered valves, cardiac remodeling stages, and even congestive heart failure) and aid in better diagnosis of the efficiency and performance of the heart. The last component of the dissertation involved the translation of my dissertation research into an engineering educational tool for undergraduate engineering students. / Ph. D.