Superhydrophobic (SHS) and lubricant-infused surfaces (LIS) exhibit exceptional non-wetting characteristics that make them attractive for energy production applications including steam condensation and fouling mitigation. The dissertation work focuses on application of non-wetting surfaces to energy production using a systematic approach examining each component of surface fabrication in three functional areas. First, SHS and LIS are fabricated using robust, scalable methods and tested for durability in heated, wet conditions and under high-energy water jet impingement. Clear performance differences are shown based on surface texturing, functionalizing agent, and infused lubricant. Second, SHS and LIS are applied to tube exteriors and evaluated for their ability to produce sustained dropwise condensation in a typical power plant condenser environment. The surfaces are shown to produce heat transfer coefficients up to 7-10 times that of film-wise condensation, with condenser effectiveness of 0.92 or better compared to effectiveness of about 0.6 in conventional condensers. Third, LIS on the interior of tubes are assessed in accelerated mineral fouling conditions. LIS are shown to mitigate calcium sulfate and calcium carbonate fouling under laminar conditions. The results of the study bear profound benefits to reducing the levelized cost of condensers and water uptake in thermoelectric power plants, that currently consume about 50% of the total water use in the U.S. / Doctor of Philosophy / Creating durable, hybrid surfaces for improved steam condensation and fouling mitigation would provide substantial impact to power generation worldwide. Bioinspired, non-wetting surfaces, such as superhydrophobic (SHS) and lubricant-infused surfaces (LIS) exhibit exceptional non-wetting characteristics that make them attractive for energy applications. Each of these non-wetting technologies, however, faces durability and scalability challenges that make them unfeasible for widespread, practical adoption. As a result, decades of materials science research have stagnated in the research laboratories with limited demonstrations of dropwise condensation and fouling mitigation in static situations. The dissertation work focuses on application of SHS and LIS to energy production using a systematic approach examining each component of surface fabrication in three functional areas. First, SHS and LIS are fabricated using robust, scalable methods and tested for durability using ASTM standard static and dynamic evaluation methods. Clear performance differences are shown based on surface texturing, functionalizing agent, and infused lubricant. Second, dropwise steam condensation on the surfaces are shown to exhibit heat transfer performance an order of magnitude greater than film-wise condensation in a typical power plant condenser environment. The surfaces are shown to produce heat transfer coefficients up to 7-10 times that of film-wise condensation, with condenser effectiveness of 0.92 or better compared to effectiveness of about 0.6 in conventional condensers. This work presents for the first time, a non-dimensional correlation for a priori prediction of LIS heat transfer performance given known qualities of the LIS. Third, challenges of fouling mitigation in power plants have been studied for over a decade. This work demonstrates for the first time that LIS applied to the interior of tubes mitigate calcium sulfate and calcium carbonate fouling in both static and laminar flow conditions.