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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Role of Id-1 in proliferation and survival of esophageal carcinoma cells

Hui, Cheuk-man., 許卓文. January 2004 (has links)
published_or_final_version / abstract / toc / Anatomy / Master / Master of Philosophy
22

Molecular genetics of B- and T-lymphocyte development /

Wikström, Ingela, January 2006 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2006. / Härtill 3 uppsatser.
23

Regulation of cortical neuron and astrocyte differentiation by the basic helix loop helix protein Hes6

Jhas, Sumit. January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Neurology and Neurosurgery. Title from title page of PDF (viewed 2008/05/14). Includes bibliographical references.
24

ZNF451 is a novel binding partner of the bHLH transcription factor E₁₂

Zhou, Shengli. January 2008 (has links)
Thesis (M.S.)--University of Toledo, 2008. / "In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 49-62.
25

Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion

Zhang, Xiaomeng. January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
26

The roles of Nkx2.2 in determination of mouse islet cell fates /

Chao, Christina Seng. January 2007 (has links)
Thesis (Ph.D. in Cell & Developmental Biology) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 144-158). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
27

The role of HEB and E2A in the regulation of T Lymphocyte development and proliferation

Wojciechowski, Jason January 2007 (has links)
Thesis (Ph. D.)--Duke University, 2007. / Includes bibliographical references.
28

RBP-L and RBP-J have critical roles in the function of two forms of the pancreas transcription factor complex PTF1

Beres, Thomas Matthew. January 2005 (has links) (PDF)
Thesis (Ph. D.) -- University of Texas Southwestern Medical Center at Dallas, 2005. / Vita. Bibliography: 163-187.
29

Basische Helix-Schleifen-Helix Transkriptionsfaktoren in Arabidopsis thaliana eine genomweite Studie zu Struktur und Funktion /

Heim, Marc Anton. Unknown Date (has links) (PDF)
Universiẗat, Diss., 2003--Köln.
30

Regulation of HLH-2/E2A during Caenorhabditis elegans gonadogenesis

Benavidez, Justin M. January 2021 (has links)
Organisms are comprised of many cells with multiple distinct cell types, each of which must be decided precisely to ensure proper formation of a functional organism. In C. elegans, the basic helix-loop helix transcription factor HLH-2 is required for the specification of the anchor cell, or AC. The AC arises from a group of four somatic gonad cells, all of which initially express HLH-2. Two of the four cells, which we call β cells, lose AC competence early and instead become ventral uterine precursor cells, or VUs. We call the remaining two cells α cells. One α cell becomes the AC, while the other becomes a VU. Which α cell becomes the AC is random—50% of the time one α cell becomes the AC, while the other 50% of the time the other α cell becomes the AC. The choice of which cell becomes the AC and which becomes the VU is called the AC/VU decision, and occurs through reciprocal signaling by LIN-12/Notch and its ligand LAG-2/DSL. At first, both α cells express similar levels of lin-12 and lag-2. As the AC/VU decision progresses, the AC expresses higher levels of lag-2, and the VU expresses higher levels of lin-12. By this time, HLH-2 is only present in the specified AC, while it is post-translationally degraded in VUs. The mechanism by which HLH-2 is degraded and the consequences of disrupting its degradation on AC specification are unknown. In this work, we studied the function and regulation of HLH-2 during two stages of somatic gonad development. First, we used long-term fluorescence microscopy to visualize HLH-2 over the course of somatic gonad development. We found that HLH-2 expression begins in the parents of the α and β cells a consistent amount of time after their birth, and that the parent cell that first expresses HLH-2 almost always gives rise to the α cell that becomes the VU, while the second cell to express HLH-2 gives rise to the AC. This led us to study the effect of a loss of hlh-2 activity in the α and β cells. We generated an α and β cell-specific hlh-2(0) allele using genome editing tools and found that LIN-12 protein is not present in the absence of hlh-2 activity. Based on this discovery, we conceived a model where HLH-2 expression biases the first-expressing cell towards the VU fate by endowing it with an edge in lin-12 activity. Next, we focused on restriction of HLH-2 to the AC. Typically, HLH-2 protein is degraded in VUs, which we hypothesized was a crucial step in restriction of the AC fate to a single cell. We found that in a lin-12(0) background, HLH-2 is stabilized in VUs even when the resulting cell does not become an AC, indicating that lin-12 directly promotes HLH-2 degradation. This led us to search for a lin-12-regulated factor that targets HLH-2 for degradation in VUs. We identified seven ubiquitin-related genes whose depletion resulted in stabilized HLH-2 in VUs, but surprisingly did not cause an AC/VU defect. We suspect that HLH-2 degradation in VUs is one of multiple negative regulatory mechanisms that ensure the robustness of the AC/VU decision. The following research contributes new insights into how stochastic cell fate decisions amplify noise to ensure a consistent and reproducible outcome.

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