Studies were conducted in the field from 2018-2019 in peanut to optimize weed control through application methods and herbicide choices. The herbicide studies were established in Mississippi, Oklahoma, Florida, and Alabama. Across trials, programs that included imazapic POST improved weed control at 28 days after treatment (DAT). The most effective PRE herbicides were flumioxazin, diclosulam, and S-metolachlor, while the use of pendimethalin was less effective. Various nozzles and operating pressures were evaluated for weed control in peanut. Droplet size was measured for each of the nozzles used at all operating pressures tested to determine classification. Classification was determined using the ASABE S572.2 standard. There was no effect on weed control or yield based on nozzle type or application pressure.