Die Habilitationsschrift beinhaltet eine zusammenfassende Darstellung unterschiedlicher Marker der biologischen Psychiatrie. Hierzu wurden mittels neuroendokriner und molekulargenetischer Verfahren depressive Patienten, alkoholabhängige Patienten und schizophrene Patienten mit einer seltenen Arzneimittelnebenwirkung untersucht und die jeweiligen Befunde als State- Trait- und Residualmarker charakterisiert. Im Bereich Neuroendokrinologie wurden der Dex/CRH-Test und Liquoruntersuchungen bei depressiven Patienten und die Apomorphin-induzierte HGH-Sekretion bei alkoholabhängigen Patienten durchgeführt. Im Bereich Pharmakogenetik erfolgten molekularbiologische HLA-und Enzymsystemuntersuchungen bei Patienten mit einer Clozapin-induzierten Agranulocytose. Es zeigten sich folgende Charakterisierungen einzelner Substrate: * HHN-Systemveränderungen (messbar über Cortisol- und ACTH-Serumkonzentrationen) sind State-bzw. Residualmarker der Depression. CRH-, AVP-und Somatostatin-Liquorkonzentrationen sind keine biologischen Marker der Depression * Das HGH-"Blunting" alkoholabhängiger Patienten ist ein spezifischer Marker für Alkoholabhängigkeit mit ungünstigem klinischen Verlauf * Spezifische HLA-Haplotypen sind als Traitmarker der Clozapin-induzierten Agranulocytose zu werten. Enzymsystem-Polymorphismen haben keine Bedeutung bei der Entwicklung dieser Arzneimittelnebenwirkung Der spezifischen Charakterisierung einzelner Befunde schließt sich eine Diskussion über deren Bedeutung für die biologische Psychiatrie an. / Neuroendocrine and pharmacogenetic studies were performed in depressive and alcohol-dependent patients as well as schizophrenic patients with clozapine-induced agranulocytosis to characterize different serological or molecular substrates as state-, trait or residualmarker. Depressive patients were assessed using the dexamethasone/corticotropin releasing hormone test and measuring neuropeptide hormone concentrations in cerebrospinal fluid (CSF), whereas dopaminergic responsiveness of alcohol-dependant patients was assessed by the apomorphine-induced human growth hormone (HGH) secretion. HLA-subtyping and screening of relevant polymorphisms of clozapine metabolizing enzyme systems was performed in patients with clozapine-induced agranulocytosis (CA). * HPA-alterations as a function of cortisol-and ACTH serum concentration appear as state- and residual marker of depression. CSF-CRH, -AVP and -SOM do not fulfill marker criteria * HGH blunting may serve as a residual marker of alcoholism with poor clinical outcome * HLA alleles but not polymorphisms of clozapine metabolizing enzyme systems are associated with CA and thus, underline the importance of imunogenetic mechanisms in the pathophysiology of this idiosyncratic drug reaction. In conclusion, the importance of biological markers for psychiatric research and future directions are discussed

<p>The purpose of this master thesis has been to develop a baggage handling process at Stockholm Skavsta Airport that is cost-efficient, in order to prepare for the expected expansion of the airport. When developing the new process it was a directive to examine the possibilities of using radio frequency identification, RFID, technology and also that the required investment for the new process should have a payback time of no more than two to three years. The current process contains a completely manual sorting activity, which is both costly in terms of personnel and creates some mishandling of baggage due to the human factor. Our recommendation is a baggage handling process that use automatic sorting through RFID technology that eliminates the mishandling of baggage and reduce the personnel costs and at the same time have a payback period of less than three years. The main cost driver is the RFID tag costs and therefore our process is a so called closed-loop system, where the tags are reused several times and require very little work in between uses. The proposed physical layout consists of a drawing of the physical layout of the baggage sorting hall, a description of the RFID system, and the required information system software.</p>

The purpose of this master thesis has been to develop a baggage handling process at Stockholm Skavsta Airport that is cost-efficient, in order to prepare for the expected expansion of the airport. When developing the new process it was a directive to examine the possibilities of using radio frequency identification, RFID, technology and also that the required investment for the new process should have a payback time of no more than two to three years. The current process contains a completely manual sorting activity, which is both costly in terms of personnel and creates some mishandling of baggage due to the human factor. Our recommendation is a baggage handling process that use automatic sorting through RFID technology that eliminates the mishandling of baggage and reduce the personnel costs and at the same time have a payback period of less than three years. The main cost driver is the RFID tag costs and therefore our process is a so called closed-loop system, where the tags are reused several times and require very little work in between uses. The proposed physical layout consists of a drawing of the physical layout of the baggage sorting hall, a description of the RFID system, and the required information system software.