Magister Curationis / Herbal and homeopathic compounds have been used to aid in childbearing and pregnancy for centuries. Much of this information is anecdotal and lacks scientific support, making it difficult to evaluate safety and efficacy. Increased public interest in alternative treatments leads to the need for a systematic review on the topic. Herbal remedies are most often used to treat the most common pregnancy-related problems like nausea, stretch marks and varicose veins. In contrast to this, concerns have also been raised about the adverse effects of these remedies. The primary objective of this research project was to conduct a systematic review to assess the maternal and neonatal outcomes of ingested herbal and homeopathic remedies using during pregnancy, birth and breastfeeding. / South Africa

M. Tech. / Since year zero of the HIV/AIDS pandemic, homosexuality has been linked to HIV/AIDS (Hooper; 2000). HIV positive homosexual individuals, therefore, are exposed to double stigmatisation; that of being homosexual and of being infected with HIV/AIDS. Taking into account the link between psyche, neural and immunological function, the above statement directly impacts the pathophysiology and prognosis of HIV/AIDS (Forrest and Kanbus; 2004) (De Kooker; 2002). This study examines the psychological and emotional states of the subjects, which are influenced, not only by their disease state but also by social stigmatisation. The aim of the study is to obtain a comprehensive homoeopathic symptom picture of HIV positive homosexual males within a South African context, compare this to existing homoeopathic symptom pictures, discuss HIV/AIDS in terms of miasmatic theory and consider possible homoeopathic treatment options for HIV/AIDS. This is a qualitative pilot study. Fourteen HIV positive homosexual males, of varying race, were recruited through Caritas Care and interviewed in Gauteng. The participants were between the ages of twenty and fifty and in stage one to three of HIV infection. Six of the participants were on antiretroviral therapy, eight not. The participants were interviewed using set questionnaires and underwent a physical examination. The interview transcripts were analysed and compared to each other then commonalities extracted to obtain a composite symptom picture. The composite symptom picture was compared to existing genus epidemicus symptom pictures and existing nosode proving pictures. The composite symptom picture was analysed using Cara Pro computerized repertorisation to determine possible treatment options. This computer programme affords the user access to multiple repertories simultaneously for rubric selection, and then analyses the case allowing for the use of different strategies. The composite symptom picture was also analysed in terms of miasmatic characteristics. The study concludes that the composite symptom picture partially matches existing HIV/AIDS genus epidemicus symptom pictures and nosode proving pictures. The composite symptom picture exhibits prominent themes of mental and emotional restlessness, generalized weakness, rebelliousness, desire for control and a desire for warmth. Possible treatment options are indicated. The include the remedies Sepia, Apis mellifica, Bryonia alba, Iodium and Natrum carbonicum but particularly of the Flouratum mineral group remedies such as Calcarea fluorica and Acidum flouricum. The study indicates that HIV/AIDS is emerging as a new miasm exhibiting characteristics of the Sycotic and Tuberculinic miasms. / Dr. L. Solomon Dr. T. Blake

M. Tech. / The climacteric describes the ongoing changes and symptoms, of the phase or transition period that may last 15-20 years in a woman’s lifecycle, when ovarian function and hormonal production declines. Menopause is the permanent cessation of the menses, identified retrospectively after one year without menses and occurs within this period of climacteric (Bernstein et al. 1996). The most common symptoms of climacteric include hot flushes, night sweats, sleep disturbances, nervousness, depressive moods, feelings of vertigo, inability to concentration, joint pain, headache and heart palpitations. The most commonly used allopathic medication to palliate these symptoms is hormone replacement therapy (HRT). There are adverse side effects and risks associated with this treatment and not all women feel better on HRT (Stoppard, 2001). The aim of this research study was to determine the efficacy of the Homoeopathic complexes Dr Reckeweg R10® and R20® (Homoeopathic complexes) in relieving the symptoms of the climacteric. The methodology and Ethics were accepted by Higher Degrees Committee and Academic Ethics Committee on the 25 August 2008 (Ethical clearance no: 40/08). Participants were recruited by advertisements (Appendix A) at the University of Johannesburg, in health food shops and in pharmacies. This was a double blind, placebo controlled study involving thirty-two participants who were divided into two matched groups based on the severity of the menopausal symptoms. Volunteers were selected using the exclusion and inclusion criteria. Volunteers meeting the inclusion criteria completed the information and consent form (Appendix B), and a patient profile and case history (Appendix C) were taken. The participants were randomly allocated to an experimental or control group, and given sets of medication (Remedy A and B, 50ml bottles) to take for a period of eight weeks (Appendix D). The participants took 10 drops of Remedy A (R10® or placebo) in the morning and Remedy B (R20® or placebo) at night. The participants were requested to complete the abbreviated Kupperman Menopause Index (KMI) weekly. The abbreviated KMI (Appendix E) scores were added v up on the participant’s full KMI (Appendix F) at the end of the trial (Kupperman et al. 1959). The results of this study showed that treatment with the Homoeopathic complexes Dr Reckeweg R10® and R20® was significantly effective in alleviating the climacteric symptoms.

MTech

Thesis submitted in partial compliance with the requirements for the Master's Degree in Technology: Homoeopathy at the Technikon Natal, 2003. / This was a double blind clinical trial, which included both quantitative and qualitative methods of analyses. A placebo group was compared with a treatment group, in order to establish whether or not homoeopathic treatment of dysthymic and adjustment disorder, in conjunction with rational behaviour therapy, altered patient score ratings in terms of the beck depression and yupi inventories. In depth interviews where conducted with each of the participants and content analysis was performed on each individual file. / M

Homoeopathy is a system of medicine used in obstetric prescribing to reduce the minor common complications of pregnancy (Cure, 1999). One such complication is haemorrhoids. Haemorrhoids are varicosities of the haemorrhoidal plexus in the rectum, and are often complicated by inflammation, thrombosis and haemorrhage (Beers & Berkow, 1999). The aim of the study was to determine the effect of homoeopathic similimum treatment on haemorrhoids in pregnant women. This was a quantitative, interventive and descriptive study spanning one month. The research method used homoeopathic similimum treatment and a participant administered questionnaire in a panel longitudinal, in-depth case study. Non-probability purposive sampling was used to select 12 primigravida or multigravida pregnant females, aged 18-35, from the 12th to 35th week of gestation, presenting with haemorrhoids, who met the inclusion criteria. The sample was obtained by advertisements placed in antenatal classes, private clinics and pharmacies; and by pamphlets handed out at Baby City shops and baby expositions to pregnant women; and referrals from health care providers. The similimum medicine was selected after an initial consultation and physical examination. The symptoms of the initial consultation were noted on a case taking form. The similimum medicine was prescribed in potency between 5CH and 200CH. Dosage was determined by the laws of similimum prescribing. Questionnaires relating to the patients symptoms were completed by the patient daily during the duration of the study. A follow up consultation and physical examination was conducted at the end of the 2nd week of treatment. As indicated by the symptoms at the follow up consultation, a new similimum was prescribed; the original similimum was continued; or it was decided to wait and watch the action of the medicine in the participant if there were signs of improvement. A final consultation and physical examination was conducted at the end of the 4th week of treatment to document the effectiveness of the treatment. The questionnaire was collected. The symptoms of both follow up consultations were noted on a follow up form. Data obtained from the questionnaires were analysed. An ordinal regression, time 1 vs. time t - 1 analysis, regression using sums and a reliability analysis were performed. The data from the individual consultations were used to write up an in depth case study. Eighty three percent (10/12) of the cases of haemorrhoids in pregnancy improved on homoeopathic similimum treatment. Homoeopathic similimum medicine had a significant effect on decreasing the severity of the pain (p < 0.00) and protrusion (p < 0.00). Besides the improvement to the haemorrhoids, there were also signs of improvement to some of the concomitant symptoms experienced by the participants. In conclusion, homoeopathic similimum treatment within a clinical setting is effective in relieving the symptoms of haemorrhoids in pregnant women. Further research needs to be conducted in order to verify these findings. / Dr. Candice Bodkin Dr. Elizabeth Solomon

Oedema is the presence of excess fluid in the body tissues (Guyton & Hall, 1997). During long air flights, blood pools in the body tissues due to decreased muscle movement. This causes bilateral ankle oedema and results in an increased risk of deep vein thrombosis as well as discomfort to the passengers after their flight (Hope et al., 2001). Hamamelis virginica is clinically indicated as a homoeopathic remedy which acts upon the venous system (Nash, 2002). Apis mellifica, Apocynum cannabinum, Natrum muriaticum and Natrum sulphuricum are all homoeopathic remedies used in the treatment of oedema. The aim of this study is to ascertain the efficiency of the Homoeopathic complex formula, Hamamelis virginica 30cH, Apis mellifica 6cH, Apocynum cannabinum 6cH, Natrum muriaticum 6cH and Natrum sulphuricum 6cH in the treatment of swelling (bilateral oedema) in the lower extremities in women during and after long air flights. This study is a double blind, placebo controlled trial. Forty female participants, between the ages of eighteen to thirty-nine, with a previous history of ankle swelling after long air flights and who were planning long air flights of eight hours or more, were recruited by means of advertisement for this study. Participants meeting the inclusion criteria underwent an examination and were matched in terms of age and risk factors; weight, cigarette smoking, oral contraception, alcohol and coffee consumption. The participants within the matched pairs were then assigned to one of two groups. One group was randomly assigned the experimental group and the other the control. Participants were required to take six powders sublingually without water. The first powder was taken two hours before the actual flight. The second, third and fourth powders were taken every two and a half hours during the course of the fight and the fifth powder was taken after the flight landed. The sixth powder was taken the day after the flight. The participants were measured by the researcher (Appendix D), measuring the circumference of their calf, ankle and foot. The participants were instructed to do three measurements, the first on the day of their flight, the second on the day they arrive at their destination and the third, on the day after their last dose of medication. The measurements were recorded and a questionnaire completed (Appendix E). The data obtained from the participants measurement and questionnaire form was statistically analysed using the repeated measures test, paired t-test, descriptive statistics the crosstab, and the Huynh-Feldt test. Statistical analysis showed significant differences, P<0.05, between the control and medicated groups for the measurements in centimetres of the left ankle and right ankle. The results obtained from the research show that the homoeopathic complex medication in this study significantly reduces lower extremities oedema during long air flights, as compared to the control group. The control group, on the other hand, did show an increase in measurements of the lower extremities during the air flight. This implies that the placebo did not provide any benefit towards reducing the oedema of lower extremities in women during long air flights. Therefore the null hypothesis was rejected Preliminary findings suggest that the homoeopathic complex preparation of Hamamelis virginica 30cH, Apis mellifica 6cH, Apocynum cannabinum 6cH, Natrum muriaticum 6cH and Natrum sulphuricum 6cH, is effective in reducing the oedema of ankles during long air flights but more research is needed to confirm these findings. / Dr. E.M. Solomon Dr. J.L. Schultz

M.Tech. / It is estimated that 4.5 million South Africans have hypercholesterolaemia. Atherosclerosis and stroke-related conditions have been identified by the South African Department of Health as priority diseases (South African Department of Health, 1998). Hypercholesterolaemia was estimated to have caused 4.6% of all deaths in South Africa in 2000 and is therefore an important cardiovascular risk factor in all population groups in South Africa (Norman et al, 2007). Panax ginseng is the botanical name for the plant commonly known as Korean ginseng. It is part of the Araliaceae botanical family. Korean ginseng has pharmacological actions including lowering serum cholesterol, improved functioning of the pituitary adrenal axis, enhanced protein synthesis and protection of the liver from hepatotoxins (Murray and Pizzorno, 2000a). The aim of the research was to evaluate the effect of Panax ginseng 1X on the total plasma cholesterol level of adult males between the ages of eighteen and fifty years. A sample group of thirty participants was recruited. Interested participants attended an initial interview where they were screened using a questionnaire and physical examinations and were instructed to have a blood test done to determine whether they qualified to take part in the study. Inclusion criteria comprised: adult males between the ages of eighteen and fifty years, total plasma cholesterol level between 4.0 and 6.19 mmol/l and not more than one major cardiovascular risk factor as classified by the U.S Department of Health and Human Services (U.S Department of Health and Human Services, 2001). Participation in the study was voluntary and participants were free to refuse treatment or withdraw from the study at any time. Since standardised Panax ginseng in normal therapeutic doses is rarely associated with side-effects, the anticipated risk for participants in the study was minimal (Murray and Pizzorno, 2000a). The total plasma cholesterol levels were measured by Lancet Laboratories. Body weight was measured and a clinical cardiovascular examination was performed by the researcher. Reliability and validity of clinical investigations was ensured by adherence to procedural documentation. The study was performed in a randomised, double-blind, placebo controlled manner. Participants were divided into two groups of fifteen. For the first four weeks of the trial no treatment was given to either group. After the first four weeks the participants attended a follow-up visit and the total plasma cholesterol level of each participant was retested. The experimental group then received Panax ginseng 1X and the control group received a placebo. Sufficient treatment for a period of eight weeks was issued to both groups. Participants were instructed to take 1.5 ml three times daily in 100 ml of water fifteen minutes before meals and were informed not to make any substantial changes to their lifestyle that could affect plasma cholesterol levels. Such lifestyle changes included alterations of diet, amount of exercise, alcohol or tobacco consumption, sleep pattern and stress levels. Patients attended a follow-up visit after taking the treatment for four weeks and the total plasma cholesterol levels were determined again at the end of the study. Collected data was analysed using descriptive statistics (frequencies and percentages). The total plasma cholesterol level of the experimental group was compared to the total plasma cholesterol level of the placebo group as obtained at the initial consultation, after four weeks and at the conclusion of the study. Groups were compared using independent samples t-tests within each sample group. Differences over time were analysed using dependent samples t-tests and repeated measures ANOVA. Panax ginseng 1X did not provide a statistically significant change in the total plasma cholesterol levels. The use of Panax ginseng is rarely associated with side-effects and in this particular study none were experienced by the participants.

Dissertation submitted in partial compliance with the requirements for the Master's Degree in Technology: Homoeopathy, Technikon Natal, 1999. / The purpose of this placebo-controlled study was to evaluate the efficacy of the homoeopathic simillimum treatment in halitosis in terms of the volatile sulphur compounds being measured objectively by the portable sulphide monitor and subjectively by organoleptic measurement\x87 / M

M. Tech. / Onychocryptosis is the diagnostic term for an ingrown toenail. It is a common and painful condition that occurs either when the nail grows into the skin on the lateral or medial side of the toe, or if the skin on the side of the toenail grows over the edge of the nail. Magnetis Polus Australis is a homoeopathic remedy recommended in the Homoeopathic Materia Medica specifically for the treatment of onychocryptosis. In previous studies, Rohl (2003) used the remedy Magnetis Polus Australis in a 7cH and a 30cH potency whereas Khan (2004) used it in a 200cH and a 1M potency. Their studies showed promising results but had sample sizes too small for definitive conclusions. In their respective studies, they recommend using Magnetis Polus Australis 2M in a single dose. The present study was aimed at determining the efficacy of Magnetis Polus Australis in treating symptoms of onychocryptosis such as pain in the big toe (hallux), tenderness to pressure, infection, erythema and oedema of the lateral nail fold in two different potencies, namely 30cH in repeated doses and 2M in a single dose. This study was a six week double-blind, placebo controlled study involving forty participants. Pre-diagnosed onychocryptosis participants were recruited and randomly divided into three groups. The first experimental group received a once-off dose of Magnetis Polus Australis 2M powder and a 50ml bottle of placebo liquid. The second experimental group received a once-off placebo powder and a 50ml bottle of 30cH Magnetis Polus Australis liquid. The control group received a once-off placebo powder and a 50ml bottle of placebo liquid. All powders were taken immediately in the presence of the researcher, whereas the 50ml liquids were taken home to be taken as ten drops under the tongue twice daily for the total six week study. After the initial consultation, there were two more follow-up consultations at three weekly intervals. At each follow-up consultation all symptoms of the condition were observed, namely pain in the big toe (hallux), tenderness to pressure, infection, erythema and oedema of the lateral nail fold, and were recorded in respect of each participant (Appendix D and E). At the end of the clinical trial all the recorded data were analyzed and compared using Fisher Exact Tests (FET) according to the symptoms of onychocryptosis. Results showed no significant difference between the experimental and control group and therefore did not confirm the efficacy of Magnetis Polus Australis as a specific treatment for the symptoms of onychocryptosis. The only finding was that the control had a significant improvement in pain as opposed to the experimental group. A possible explanation is that the experimental groups, especially the 2M group, demonstrated a homoeopathic aggravation. Further research on this topic is required with a larger sample group over a longer time period.