The state of critically ill patients suffering from polytrauma or sepsis is characterised by pathophysiologic processes, which cause significant changes in an organism on both a local and a systematic level. A stressful situation elicits an acute inflammatory response. This response is primarily meant to be a defence mechanism; however, this mechanism might become harmful to a certain degree. Hormones, cytokines and growth factors are included among the main control mechanisms activated during inflammatory response. A metabolic response to a stressful situation is characterized by an increased turnover of proteins, lipids, and glucose. Clinical consequences may develop as a result of these metabolic responses and include inflammation, anorexia, immobility, increased vascular permeability (which results in edema), vasodilation, tachycardia, and increased cardiac output. There are some key factors which have a negative contribution on an inflammatory response. Those factors may include malnutrition, pre-existing inflammatory activity, severe infection, obesity, ageing, genotype, and finally gender-gene effects, which may also play a role. The development of significant hormonal changes can be typified for critically ill patients. Such changes are particularly connected to catecholamines, thyroid...

Pirmą kartą buvo atlikti morfologiniai sutrikusios reprodukcijos paršavedžių endometriumo tyrimai, nustatyti endometriumo paviršinio ir liaukinio epitelio aukščio poky��iai, imuninių ląstelių infiltracija, PR-A ir ERα lokalizacija skirtingų lytinio ciklo stadijų ir patologinės anoestrus būklės metu. Nustatyta gonadotropinių hormonų (FSH, LH) poveikio įtaka progesterono (PR-A) ir estrogenų (ERα) receptorių kiekio ir lokalizacijos pokyčiams. Darbo tikslas: įvertinti įvairių veiksnių įtaką laikotarpio trukmei nuo paršelių atjunkymo iki paršavedžių rujos požymių pasireiškimo ir nustatyti morfologinius pakitimus bei estrogenų receptorių alfa (ERα) ir progesterono receptorių A (PR-A) pasiskirstymą sutrikusios reprodukcijos paršavedžių gimdoje lytinio ciklo ir patologinės anoestrus būklės metu. / Aim of the research: The aim of this research was to evaluate the effect of various factors on the duration of the period from piglets weaning to oestrus manifestation and to define morphological changes and distribution of estrogen receptors (ERα) and progesterone receptors A (PR-A) in the uterus of sows with disturbed reproduction during the oestrus cycle and pathological anoestrus condition. Novelty of the research: Morphological investigations of sows with disturbed reproduction endometrium were carried out for the first time, changes of luminar endometrial epithelium and glandular epithelium height, infiltration of the immune cells, PR-A and ERα localization during different stages of oestrus cycle and pathological anoestrus condition were studied. The effect of the number of gonadotropic hormones (FSH, LH), progesterone (PR-A) and estrogen (ERα) receptors and localization changes was studied.