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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.282 seconds)

Spelling suggestions: "subject:"human secretase"" "subject:"human seacretase""

1

Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

Linning, Philipp, Haussmann, Ute, Beyer, Isaak, Weidlich, Sebastian, Schieb, Heinke, Wiltfang, Jens, Klafki, Hans-Wolfgang, Knölker, Hans-Joachim 08 April 2014 (has links) (PDF)
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Amyloid-Precursor-Protein
APP
Alzheimer-Krankheit
Beta-Sekretase
BACE1
Alzheimer's disease
amyloid precursor protein
human beta-secretase
lipid rafts
manganese-dioxide
design
discovery
cleavage
iodides
enzyme
esters
ddc:540
rvk:VA 1120
2

Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

Linning, Philipp, Haussmann, Ute, Beyer, Isaak, Weidlich, Sebastian, Schieb, Heinke, Wiltfang, Jens, Klafki, Hans-Wolfgang, Knölker, Hans-Joachim January 2012 (has links)
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
info:eu-repo/classification/ddc/540
ddc:540

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