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Background : The oral administration of Glucosamine and intra-articular (IA) injection of Hyaluronic Acid were used to treat osteoarthritis. Several studies supported that clinical pain symptoms could be alleviated, and activities of daily life improved after the completion of IA knee hyaluronic acid injections. However, the efficacy of oral administration of Glucosamine was inconclusive. In Taiwan, the Taiwan's National Health Insurance (NHI) made the strict formulations for the both of ¡§oral administration of Glucosamine ¡§and ¡§IA knee hyaluronic acid injections.¡¨ But, there were no evidence to prove that whether the combined treatments from both oral administration of Glucosamine and IA knee hyaluronic acid injections were more effective than the treatment with the IA knee hyaluronic acid injections alone. Objectives : The porpose of this study was to examine whether the effects of treatment combined with both ¡§oral administration of Glucosamine and IA knee hyaluronic acid injections¡¨ on clinical pain symptoms and activities of daily living were better than ¡§IA knee hyaluronic acid injections¡¨ alone. Methods : We randomly assigned 60 patients with symptomatic knee osteoarthritis, at the department of Orthopedics, Kaohsiung Municipal Union Hospital, between 2008 and 2009, to receive oral administration of Glucosamine and IA knee hyaluronic acid injections or oral administration of Placebo and IA knee hyaluronic acid injections. In this study, clinical pain symptoms, and activities of daily living were assessed by using Lequesne's Index, visual analogue scale index, Berg Balance Test, and Biodex Balance Test before and after the treatment in 60 patients with the knee OA. Result : The mean age was 66.6 years, and 70 percent were woman. There was a significant efficacy before and after treatments both in the treatment group(p<0.001) and the placebo control group(p<0.001). In the other hand, there was not the statistical significance in the efficacy between the treatment group and the control group(p=0.869). Conclusion : The combined treatment with both oral administration of Glucosamine and IA knee hyaluronic acid injections was not significantly better than the IA knee hyaluronic acid injections alone in reducing knee pain or promoting the function of daily life.

Thesis (Ph. D.)--University of Texas at Austin, 2003. / Vita. Includes bibliographical references. Available also from UMI Company.

Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / The mammalian hyaluronidases represent a family of enzymes that can degrade hyaluronan. This thesis examines the properties of hyaluronidase-1 and hyaluronidase-3, as well as the production of hyaluronan and the expression of hyaluronidase and hyaluronan synthases in mineralising osteoblasts. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1278426 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007

Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / The mammalian hyaluronidases represent a family of enzymes that can degrade hyaluronan. This thesis examines the properties of hyaluronidase-1 and hyaluronidase-3, as well as the production of hyaluronan and the expression of hyaluronidase and hyaluronan synthases in mineralising osteoblasts. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1278426 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007

Diss. (sammanfattning) Umeå : Umeå universitet, 2006. / Härtill 4 uppsatser.

Thesis--Auburn University, 2007. / Abstract. Includes bibliographic references (p.30-40).

Thesis (D.Eng.)--Cleveland State University, 2008. / Abstract. Title from PDF t.p. (viewed on July 7, 2008). Includes bibliographical references (p. 150-176). Available online via the OhioLINK ETD Center. Also available in print.

Thesis (Master)--İzmir Institute of Technology, İzmir, 2005. / Keywords: Iontophoresis, Hyaluronic acid Includes bibliographical references (leaves. 94-105).