The rapid advancement of web and mobile application technologies has recently posed numerous challenges to the Software Engineering community, including how to cost-effectively test applications that have complex event spaces. Many software testing techniques attempt to cost-effectively improve the quality of such software. This dissertation primarily focuses on that of hybrid test suite prioritization. The techniques utilize two or more criteria to perform test suite prioritization as it is often insufficient to use only a single criterion. The dissertation consists of the following contributions: (1) a weighted test suite prioritization technique that employs the distance between criteria as a weighting factor, (2) a coarse-to-fine grained test suite prioritization technique that uses a multilevel approach to increase the granularity of the criteria at each subsequent iteration, (3) the Caret-HM tool for Android user session-based testing that allows testers to record, replay, and create heat maps from user interactions with Android applications via a web browser, and (4) Android user session-based test suite prioritization techniques that utilize heuristics developed from user sessions created by Caret-HM. Each of the chapters empirically evaluate the respective techniques. The proposed techniques generally show improved or equally good performance when compared to the baselines, depending on an application under test. Further, this dissertation provides guidance to testers as it relates to the use of the proposed hybrid techniques.