Thesis--Göteborg. / Includes reprints of five supporting articles.

Thesis--Göteborg. / Includes reprints of five supporting articles.

Indiana University-Purdue University Indianapolis (IUPUI) / The study compared pulp reactions to a synthetic hydroxyapatite and to calcium hydroxide with either one percent chlorhexidine or distilled water as a mixing vehicle. Forty-seven permanent teeth of two monkeys were mechanically exposed under aseptic conditions. The pulps were then capped with one of the following: synthetic hydroxyapatite mixed with chlorhexidine; synthetic hydroxyapatite mixed with water; calcium hydroxide mixed with chlorhexidine; calcium hydroxide mixed with water. Small square sheets of gold foil were then placed over the capping material. A base of IRM was placed and the cavities were restored with amalgam. The teeth were extracted at 14 and 90 days after pulp capping. The specimens were fixed in 10% formalin and decalcified in 5% formic acid. Serial sections 7 microns thick were prepared and stained with hematoxylin and eosin. The synthetic hydroxyapatite mixed with one percent chlorhexidine or water was well tolerated by the dental pulp. Complete bridging occurred infrequently in the specimens capped with the hydroxyapatite, compared to those capped with calcium hydroxide, which usually showed complete bridging of the exposure.

Thesis (M.S.)--University of Tennessee Health Science Center, 2008. / Title from title page screen (viewed on June 10, 2008). Research advisor: Joo Leng Ong, Ph.D. Document formatted into pages (vi, 34 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 31-34).

Thesis (Ph. D.)--University of Iowa, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Iowa, 1999. / Includes bibliographical references.

Indiana University-Purdue University Indianapolis (IUPUI) / Veillonella spp. are found in high numbers in the mouth in dental plaque and on the mucosa. Veillonellae utilize lactic acid for their metabolic needs. A symbiotic relationship between Veillonellae and other oral bacteria, including a nutritional relationship with some streptococci, has been demonstrated both in vitro and in vivo. Thus, Veillonellae may protect the host from dental caries. Adherence is the initial step in bacterial colonization of oral surfaces. Recent evidence suggests that certain oral bacteria express molecules (adhesins) on their cell surface, which recognize receptors on other oral bacteria and/or in salivary pellicle. It has been previously demonstrated that Veillonella spp. bind avidly to Streptococcus. spp. found in subgingival plaque. The present study investigated the ability of V. atypica PK1910 to bind to saliva-coated hydroxyapatite (SHA), a model for adherence to the salivary pellicle. The results show that there was statistically significant enhanced binding of Veillonella atypica PK1910 to saliva-coated hydroxyapatite beads. (p< 0.05) Three classes of coaggregation-defective mutants of V. atypica PK1910 were tested for their ability to bind to SHA. Interestingly, they did not demonstrate any enhanced binding to saliva-coated hydroxyapatite beads. Heating of PK1910 did not effect binding to SHA. In contrast, protease treatment of the veillonella cell surface inactivated binding. Therefore, it appears that V. atypica PK1910, in addition to binding to oral Streptoccoccus spp. in dental plaque, may also colonize the tooth surface by binding directly to the salivary pellicle. It appears that a distinct heat stable protein may mediate this binding to SHA.

In a 6-week rat model it was demonstrated that a small dose of peri-implant zoledronic acid (ZA) increased local bone formation 3-fold compared with controls. Ancillary in vitro studies using 14C-labeled ZA implant doses demonstrated biphasic elution profiles for implants coated with hydroxyapatite; complete ZA release occurred within one to three weeks in serum compared with only 60% ZA release after 12 weeks in water. Implants without hydroxyapatite coating showed more burst-type release profiles and full ZA elution within 24 hours of hydration in serum or water. Canine studies at 6 weeks using implants with 14C-labeled ZA showed that the compound remained localized, with the greatest ZA concentration immediately adjacent to the implant. Although there was evidence of skeletal ZA distribution via diffusion into the circulation, the levels were two orders of magnitude less than at the implant site.

Thesis (M.S.)--University of Tennessee Health Science Center, 2007. / Title from title page screen (viewed October 10, 2007). Research advisor: Joo L. Ong, Ph.D. Document formatted into pages (vi, 22 p. : ill.) Vita. Abstract. Includes bibliographical references (p. 23-32).

Thesis (M.S. )--University of Tennessee Health Science Center, 2007. / Title from title page screen (June 30, 2008). Research advisor: Joo L. Ong, Ph.D. Document formatted into pages (vi, 47 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 41-46).