NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Jaundice and Hepatorenal Syndrome Associated With Cytosine Arabinoside

Kirtley, D W., Votaw, M L., Thomas, E 01 March 1990 (has links)
A young man receiving high dose cytosine arabinoside (3g/m2 every 12 hours) for promyelocytic leukemia developed rapidly increasing hyperbilirubinemia and hepatorenal syndrome. The patient had been treated previously with courses of standard dose cytosine arabinoside without hepatic or renal complications. His condition rapidly deteriorated, and he required hemodialysis. The total bilirubin increased to 45.4 mg/dL, but alkaline phosphatase remained normal. Twelve days after starting chemotherapy, the patient died of hepatorenal failure. Liver necropsy revealed mild bile stasis and microvesicular steatosis. We suspect high dose cytosine arabinoside played a major role in causing impairment of bilirubin transport within the hepatocyte in this patient.
acute kidney injury (chemically induced
physiopathology)
adult
chemical and drug induced liver injury
cytarabine (adverse effects
therapeutic use)
humans
hyperbilirubinemia (chemically induced)
leukemia
promyelocytic
acute (drug therapy)
liver diseases (pathology
physiopathology)
male
Internal Medicine

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