This work deals with designing and testing of new acoustic features for analysis of dysprosodic speech occurring in hypokinetic dysarthria patients. 41 new features for dysprosody quantification (describing melody, loudness, rhythm and pace) are presented and tested in this work. New features can be divided into 7 groups. Inside the groups, features vary by the used statistical values. First four groups are based on absolute differences and cumulative sums of fundamental frequency and short-time energy of the signal. Fifth group contains features based on multiples of this fundamental frequency and short-time energy combined into one global intonation feature. Sixth group contains global time features, which are made of divisions between conventional rhythm and pace features. Last group contains global features for quantification of whole dysprosody, made of divisions between global intonation and global time features. All features were tested on Czech Parkinsonian speech database PARCZ. First, kernel density estimation was made and plotted for all features. Then correlation analysis with medicinal metadata was made, first for all the features, then for global features only. Next classification and regression analysis were made, using classification and regression trees algorithm (CART). This analysis was first made for all the features separately, then for all the data at once and eventually a sequential floating feature selection was made, to find out the best fitting combination of features for the current matter. Even though none of the features emerged as a universal best, there were a few features, that were appearing as one of the best repeatedly and also there was a trend that there was a bigger drop between the best and the second best feature, marking it as a much better feature for the given matter, than the rest of the tested. Results are included in the conclusion together with the discussion.

This work deals with the diagnosis of Parkinson's disease by analyzing the speech signal. At the beginning of this work there is described speech signal production. The following is a description of the speech signal analysis, its preparation and subsequent feature extraction. Next there is described Parkinson's disease and change of the speech signal by this disability. The following describes the symptoms, which are used for the diagnosis of Parkinson's disease (FCR, VSA, VOT, etc.). Another part of the work deals with the selection and reduction symptoms using the learning algorithms (SVM, ANN, k-NN) and their subsequent evaluation. In the last part of the thesis is described a program to count symptoms. Further is described selection and the end evaluated all the result.