Many applications require storage and indexing of new kinds of data in main-memory, e.g. color histograms, textures, shape features, gene sequences, sensor readings, or financial time series. Even though, many domain index structures were developed, very a few of them are implemented in any database management system (DBMS), usually only B-trees and hash indexes. A major reason is that the manual effort to include a new index implementation in a regular DBMS is very costly and time-consuming because it requires integration with all components of the DBMS kernel. To alleviate this, there are some extensible indexing frameworks. However, they all require re-engineering the index implementations, which is a problem when the index has third-party ownership, when only binary code is available, or simply when the index implementation is complex to re-engineer. Therefore, the DBMS should allow including new index implementations without code changes and performance degradation. Furthermore, for high performance the query processor needs knowledge of how to process queries to utilize plugged-in index. Moreover, it is important that all functionalities of a plugged-in index implementation are correct. The extensible main memory database system (MMDB) Mexima (Main-memory External Index Manager) addresses these challenges. It enables transparent plugging in main-memory index implementations without code changes. Index specific rewrite rules transform complex queries to utilize the indexes. Automatic test procedures validate the correctness of them based on user provided index meta-data. Moreover, the same optimization framework can also optimize complex queries sent to a back-end DBMS by exposing hidden indexes for its query optimizer. Altogether, Mexima is a complete and extensible platform for transparently index integration, utilization, and evaluation.