Thesis (Ph. D.)--University of Wisconsin--Madison, 1953. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 171-175).

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Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.

No description available.

Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 7 uppsatser.

The auxin-like properties of potassium naphthenates (KNap), and the effect of these compounds on indoleacetic acid (IAA) biosynthesis and degradation were examined. Chapter I. The auxin-like properties of KNap. Cucumber seeds were treated with 1000 ppm KNap and a significant (at the 0.05 level) inhibition of root growth (91%) , compared with control seedlings was obtained. The effects of KNap and indolebutyric acid on the initiation of roots by stem cuttings of Phaseolus vulgaris L. were examined. The treatments with 10 and 100 ppm of both compounds significantly stimulated root initiation. Root initiation of azalea stem cuttings was significantly augmented by 10, 100, and 1000 ppm KNap. The elongation of dark-grown Alaska pea stem segments was stimulated by 1.0 ppm KNap (279% over the control). Surprisingly, this stimulation did not differ significantly from that caused by 0.1 ppm IAA (339% over the control). KNap at 100 and 1000 ppm, applied to the distal end of debladed petioles, did not affect abscission. The times required for 50% abscission of petioles treated with 10 and 1000 ppm cyclohexanecarboxylic acid were significantly greater than that for abscission of control petioles, but not from that required by petioles treated with 100 ppm naphthaleneacetic acid. Chapter II. The effect of KNap on IAA biosynthesis and degradation. When the seeds of Phaseolus vulgaris L. were soaked for 12 hours in a solution of 100 ppm KNap immediately prior to sowing, there was a significant increase (140% over control plants) in the content of IAA in the apical 5-8 cm of the stems of 14-day-old plants. The immersion of the root systems of 13-day-old dark-grown bean plants in a solution of 100 ppm KNap for 24 hours resulted in a significant stimulation (4% over the control) of the activity of the IAA oxidase system. The evidence presented is interpreted as supporting the view that KNap has some auxin-like properties. The validity of this interpretation is discussed. / Science, Faculty of / Botany, Department of / Graduate

Une nouvelle voie d’accès à des structures tri-cycliques originaux les « oxazino-indole di-iodés» a été mise au point à partir des acides 1H-indole-2-carboxyliques commerciaux ou des acides 1H-indole-2-carboxyliques fonctionnalisés obtenus par la réaction d’Hemetsberger-Knittel. La dernière étape de cette séquence est une réaction d’iodocyclisation qui s’est avérée totalement régio- et stéréosélective selon un processus de type 6-exo-dig. Cette méthodologie a ensuite été étendue en série isoindolique permettant un accès à des motifs « oxazino-isoindolique di-iodés » originaux. Afin d'étendre davantage cette méthodologie, de nouveaux « oxazepino-indole di-iodés » ont été préparés en utilisant la même approche synthétique à partir de l'acide 1H-indole-7-carboxylique. La réactivité des structures tri-cycliques di-iodés a été étudiée via des réactions de Cross-Coupling (Stille, Sonogashira, Suzuki) par l’utilisation de sels de palladium permettant une fonctionnalisation régiosélective de l’iode exocyclique. / A new access pathway to the original tricyclic structures "di-iodinated oxazino-indole" was developed from the commercial 1H-indole-2-carboxylic acids or functionalized 1H-indole-2-carboxylic acid obtained by Hemetsberger-Knittel reaction. The last step in this sequence is an iodocyclisation reaction that is proved to be completely regio- and stereoselective via 6-exo-dig process. This methodology was then extended to isoindolic series allowing access to original "di-iodinated oxazino-isoindole" motifs. To further extend this methodology, new"di-iodinated oxazepino-indoles" were prepared using the same synthetic approach from the 1H-indole-7-carboxylic acid. The reactivity of the di-iodinated tri-cyclic structures has been studied via Cross-Coupling reactions (Stille, Sonogashira and Suzuki) by the use of palladium salts allowing a regioselective functionalization of the exocyclic iodine.

Several novel cascade processes have been designed and developed that involve sequential reactions of imines and iminium ions to form substituted quinolizidine ring systems in a single step from simple and readily available starting materials. The utility and promise of these cascades is evident from their application to extraordinarily concise syntheses of the representative quinolizidine alkaloids (±)-epilupinine, (±)-tashiromine, and (-)-epimyrtine. Within the context of a longstanding interest in aromatic heterocyclic natural product synthesis, a concise synthetic strategy incorporating new tactics for key chemical transformations, as well as novel applications of existing synthetic methods was developed constructing the natural product meloscine. Meloscine was isolated in the 1970's from the New Caledonian plant Melodinus Scandens Forst, which is used in Chinese folk medicine for the treatment of meningitis and rheumatic heart disease. In route to meloscine, a facile synthetic method was developed toward several carboline type indoles. Also, progress has been made toward the total synthesis of the natural product meloscine. / text

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).