Skin cancer incidence is increasing while the rates of other cancers is declining. The purpose of this quantitative study was to determine whether health self-efficacy predicted skin cancer protective behaviors. The theory of health self-efficacy provided the framework for the study. Secondary data were collected from the 2008 and 2014 Health Information National Trends Surveys. The study sample included women 18-34 years of age because this population is especially vulnerable to skin cancer. Results of logistic regression analyses indicated that higher levels of health self-efficacy predicted greater sunscreen use, but higher health self-efficacy levels did not predict avoidance of tanning bed or booth use. No significant changes were found in sunscreen use and tanning bed and booth use between 2008 and 2014. Findings may be used to develop educational programs and medical interventions to decrease the incidence of skin cancer.