The advent of technology has put a number of institutions in a state of reform (Wolcott, 1997). In fact, it was predicted that technology would completely transform higher education by the end of the twentieth century (Sculley, 1989). Aside from the demographic make-up of the majority of current students (Howe & Strauss, 2000), moving away from the traditional lecture-format to one with the integration of instructional technology can enhance the teaching/learning environment (Bolger & Sprow, 2002). However, instructional technology has still not been completely integrated into the higher education curriculum and students reported that only about 20 % of instructors were found to use technology effectively ("How Students Rate Instructors' Use of Information Technology in Courses", 2011). Educators continue to face a number of barriers to adoption and many institutions are still investigating ways to provide a more effective learning and teaching environment using efficient use of instructional technology. This research used the College of Engineering at Virginia Tech as a test bed and conducted a set of three studies following a mixed methodology. The first study elicited both quantitative and qualitative data from faculty members who used instructional technology in the classroom. Structural equation modeling was used to examine the relationships between organizational culture, usability, and instructional technology acceptance and found a significant, positive relationship between usability and instructional technology acceptance, and a positive relationship between organizational culture and instructional technology acceptance. The second study gained more insight into the relationship by collecting qualitative data in the form of focus group interviews. Results of Study 2 indicated that collaborative and innovative organizational cultures, coupled with instructional technologies that have low learnability, high efficiency, high effectiveness, and high satisfaction can facilitate instructional technology acceptance. Based on the results, a set of recommendations to facilitate instructional technology acceptance were developed. The third and final study consisted of a summative evaluation of the recommendations by a panel of experts using the Delphi technique. The overall outcome of this research effort was the development of recommendations and guidelines to facilitate instructional technology acceptance and the description of a comprehensive framework for effective instructional technology use. / Ph. D.