Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / Typescript. Vita. Includes bibliographical references (leaves 228-243). Also available on the Internet.

Medicinal plants, as part of traditional ingestion practices, may contain antioxidants to combat the oxidative stress which is implicated in prediabetes as well as many of the complications of diabetes, As Indigenous Peoples move further from their traditional lifestyles, and therefore their use of medicinal plants, incidence of diabetes has increased dramatically, Those medicinal plants of the boreal forest that have been used for 3 or more symptoms of diabetes or its complications were selected for analysis. Three different assays (DPPH, NBT/xanthine oxidase and DCF/APPH) determined the antioxidant activity of 35 medicinal plant species. The majority of the species (89%) had free radical scavenging activity significantly greater than the market produce tested (Tukey, P < 0.05), 63% had superoxide scavenging activities similar to vitamin C, and eight species had free radical scavenging activity similar to green tea. Considering that many of these species are also used for food or beverage they represent an antioxidant benefit to the traditional lifestyle. Among the parts used medicinally, roots and barks were used the most frequently with activity in the order of fruit > bark > leaves > roots. The perennials selected had activity in rank trees > shrubs > herbs and the activity associated with habitat found rocky areas > woodland > wet/boggy habitats. Species used for symptoms such as diarrhea, rheumatism, tonic and heart/chest pain were typically high in antioxidant activity. Using cluster analysis it was determined that species used for diarrhea and heart disease as well as those used for a combination of tonic, sores, urinary, blood, pregnancy and boils could also be species with high antioxidant activity. The greater the number of symptoms a species was used for, the greater the activity. Three species with high antioxidant activities, Rhus hirta, Cornus stolonifera and Solidago canadensis, inhibited TNF production in human macrophage cells suggesting a po

[Truncated abstract] Cardiovascular reflex control of the vasculature is important in maintaining adequate tissue oxygenation in the face of disturbances in physiological homeostasis. Alterations in blood oxygen levels and blood distribution evoke integrated neural, mechanical and humoral responses which modulate peripheral vasomotor tone to maintain systemic cardiovascular integrity. The balance between the local effects of hypoxia and changes in chemoreflex control of vascular tone during hypoxia determine whether net vasoconstriction or vasodilatation is evident in the peripheral vasculature. The mechanisms contributing to hypoxic vasodilatation per se have not previously been defined in healthy humans. Study 1 of this thesis (Chapter 3) investigated the mechanisms contributing to vasomotor responses to chemoreflex activation in the human forearm ... Study 2 (Chapter 4a) investigated the mechanisms controlling vasomotor responses to isocapnic hypoxia in subjects with type 2 diabetes ... Study 3 (Chapter 5) compared the vascular responses to decreased venous return in individuals with and without right atrial afferent innervation ... The results of this thesis indicate that in healthy humans isocapnic hypoxia induces sympathetic vasoconstriction, which masks underlying β-adrenoceptor mediated vasodilatation. The normal vasomotor response to isocapnic hypoxia is impaired in subjects with type 2 diabetes. Despite intact vasoconstrictor responses, subjects with type 2 diabetes exhibited attenuated adrenaline-mediated vasodilatation compared to healthy control subjects, suggesting that the chemoreflex in these subjects is ill-equipped to respond to hypoxic stress. In clinical terms, impaired reflex vasomotor

Thesis (M.D.)--University of Adelaide, Dept. of General Practice, 2005. / Includes publications published as a result of ideas developed in this thesis, inserted at end. "April 2005" Includes bibliographical references (leaves 210-242).

Thesis (M.S.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains xiii, 177 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 147-154).

Thesis (M.S.)--University of Michigan, 1991.

Thesis (Ph. D.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains xiv, 287 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 261-282).

Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5301. Adviser: Eric Boerwinkle. Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1991.

Thesis (M.S.) --The University of North Carolina at Greensboro, 2008. / Directed by Martha Taylor; submitted to the Dept. of Nutrition. Title from PDF t.p. (viewed Apr. 13, 2010). Includes bibliographical references (p. 62-65).