Following the global warming and climate change in the last twenty years, one of key actions on maintaining biodiversity is to save critical endangered species with aspect of intergrated management. Our study aims to explore integrated mechanism inside the case of Chinese White Dolphin conservation in Taiwan throught a qualitative research approach. The integrated mechanism was also understood under a concept of social-ecological system and analysed with a framework that was modified mitigation-adaptation model used to apply on climate change study. The capacity of management measures including of mitigation and adaptation was explored on three levels, i.e. animals, habitat, and society. Differences of the capacity in these three levels were compared between the cases in Taiwan and Hong Kong. The study also tried to point out possible responders who should conduct these conservation measures from a questionnaire survey. The statistical analysis revealed none of top measures must be under the responsibility of government in these three levels. The analysis showed that there is no correlation between the implementation of measures and the governmental responsibility. In addition, the top-six measures were mainly in the marine environment level and four of the measures had been implemented. In the analysis about governmental responsibility top-seven measures, should be under the responsibility of developers, instead of the government. Some suggestions were given at the end for integrated management of Chinese White Dolphin conservation in Taiwan.

Neurodegeneration is a chronic, progressive and debilitating condition that affects majority of the World's elderly population who are at greater risk. Numerous scientific studies suggest that there could be a common underlying molecular mechanism that promotes the degeneration and the subsequent neuronal loss, however so far the progress in this direction is rather limited. Abnormal protein misfoldings, as well as protein plaque formations in the brain, are some of the hallmark characteristic features of neurodegenerative disorders (NDDs). Genetic and environmental factors, oxidative stress, excessive reactive oxygen species formation, mitochondrial dysfunction, energy depletion and autophagy disruption etc. are some of the widely suspected mechanisms that manifest the cognitive, motor and emotional symptoms of these NDDs. Motivated by some molecular traits found in common in several NDDs, network-based systems biology tools and techniques were used in this study to identify critical molecular players and underlying biological processes that are common for Parkinson's, Alzheimer's and Huntington's disease. Utilizing multiple microarray gene expression datasets, several biomolecular networks such as direct interaction, shortest path, and microRNA regulatory networks were constructed and analyzed for each of the disease conditions. The network-based analysis revealed 26 genes of potential interest in Parkinson's, 16 in Alzheimer's and 30 in Huntington's disease. Many new microRNA-target regulatory interactions were identified. For each disorder, several routes for possible disease initiation and protection scenarios were uncovered. A unified neurodegeneration mechanism network was constructed by utilizing the significantly differentially expressed genes found in common in Parkinson's, Alzheimer's and Huntington's microarray datasets. In this integrated network many key molecular partakers and several biological processes that were significantly affected in all three NDDs were uncovered. The integrated network also revealed complex dual-level interactions that occur between disease contributing and protecting entities. Possibilities of microRNA-target interactions were explored and many such pairs of potential interest in NDDs were suggested. Investigating the integrated network mechanism, we have identified several routes for disease initiating, as well as alleviating ones that could be utilized in common for Parkinson's, Alzheimer's and Huntington's disease. Finding such crucial and universal molecular players in addition to maintaining a delicate balance between neurodegeneration promoters and protectors is vital for restoring the homeostasis in the three NDDs.