A numerical simulation study for an interdigitated micro-channel PEM fuel cell is presented. Hydrogen gas is supplied to the anode and air is supplied to the cathode. The fuel cell outer surfaces are maintained at a constant temperature. The SIMPLEC algorithm is employed in a control volume numerical scheme. The outflow boundary conditions are specified to all transport equations except that an outlet pressure is specified to the momentum equation. Results are compared and show good agreement with the experimental data. The effects of the mass flow rate, the outlet pressure and the cell surface temperature on the cell performance are studied. The results can provide reference for fuel cell design.