Orthogonal frequency division multiplexing (OFDM) is the major technique for next generation wireless communication system because of its high spectral efficiency. In addition, multiple-input multiple-output (MIMO) technique is usually used to further increase system capacity. There are two major coding schemes adopted in MIMO-OFDM systems, i.e. space-time block code (STBC) and space-frequency block code (SFBC). This thesis investigates the orthogonal-space-frequency block code OFDM (OSFBC-OFDM) system. In SFBC-OFDM systems, the channel frequency response is usually assumed to be the same for adjacent subcarriers. However, this assumption is not valid in frequency-selective fading environment. Therefore, the orthogonality of code structure is destroyed, leading to substantial increase in interference and significant decrease in system performance. This thesis proposes a receiver equalizer which adopts an interference cancellation (IC) mechanism to maximize the signal to interference plus noise ratio (SINR). Both the Lagrange multiplier method and eigenvalue method are adopted in the interference cancellation. Simulation experiments are conducted to verify the system performance and results demonstrate that the SINR performance is dramatically improved.