The purpose of this study was to investigate endocrine responses to redistribution with heavier loads (RR+L) during back squat (BS) exercise in resistance-trained men. Ten men (mean±SE; 23±2 years, 175.6±2.0 cm, 78.0±3.4 kg, 4±1 training years) were assigned using randomization to either RR+L (4 sets of (2×5 repetitions) of BS with 30 s intra-set and 90 s inter-set rest using 75% of their 1RM) or traditional sets (TS; 4 sets of 10 repetitions of BS with 120 s inter-set rest using 70% of their 1RM). Fasted blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 5 (+5), 15 (+15), and 30 (+30) minutes post-exercise to analyze the concentrations of testosterone (T), growth hormone (GH), cortisol (C), and blood lactate (BL). Two-way ANOVAs with repeated measures were used (p≤0.05). A main effect of condition (p=0.023) was observed for BL (RR+L; 5.9±0.5 vs TS; 6.7±0.4 mmol/L). A main effect of time point (p≤0.001) was observed for T, GH, C, and BL. T was greater at IP (8.8±1.1), +5 (9.0±1.1), +15 (8.5±1.0), and +30 (8.0±1.0) than PRE (7.1±0.8 ng/mL). GH was greater at IP (58.3±12.7), +5 (62.8±12.7), +15 (67.9±13.3), and +30 (52.8±11.2) than PRE (3.6±1.6 µIU/mL). C was greater at +15 (25.5±2.9) and +30 (25.6±2.7) than PRE (20.0±2.7 µg/dL). BL was greater at IP (8.6±0.6), +5 (8.2±0.6), +15 (7.4±0.5), and +30 (5.8±0.5) than PRE (1.4±0.2 mmol/L). RR+L resulted in lower BL but no differences in T, GH, and C responses compared to TS. Thus, practitioners may incorporate RR+L without affecting endocrine responses.