During the past decade, evidence has accumulated to indicate the possible role of the adrenal cortex in the etiology of human hypertension. The most important observations are related to the frequent occurrence of hypertension in Cushing's Syndrome as well as in certain types of congenital hyperplasia and to the affect of total adrenalectomy on malignant hypertension which has often been followed both by a substantial fall of blood pressure and by a decreased incidence of cardiovascular lesions.

The field of respiratory physiology has many facets; the literature on the subject is voluminous, and much of it is conflicting. Many facts concerning the control and mechanism of respiration have been established, but much circumstantial and indirect evidence as well as speculation have been, and are, accepted as facts. For the past hundred years physiologists have been investigating the control of pulmonary ventilation and the regulation of the respiratory cycle. [...]

The problem of human arterial hypertension has been one of the most debated subjects in modern medicine. Many groups of investigators and clinicians have been interested in its etiology, its physiopathology and its treatment. The first suggestion that the kidneys might be responsible for this disease entity came from Richard Bright in 1836,and it was the result of a remarkable clinical acumen. In 1898, Tigerstedt and Bergman injected crude saline extract of rabbit kidney into anesthetized rabbits and observed a prolonged rise in blood pressure; they named this unknown pressor principle “rennin”.

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