Thesis (Ph. D.)--California Institute of Technology, 1979. UM #79-11,639. / Advisor names found in the Acknowledgments pages of the thesis. Title from home page. Viewed 01/19/2010. Includes bibliographical references.

Thesis (Ph. D.). UM #76-06,542. Thesis (Ph. D.)--California Institute of Technology, 1976. UM #76-06,542. / Advisor names found in the Acknowledgments pages of the thesis. Title from home page. Viewed 01/19/2010. Includes bibliographical references.

Thesis (Ph. D.)--California Institute of Technology, 1997. UM #9800349. / Advisor names found in the Acknowledgments pages of the thesis. Title from home page. Viewed 01/21/2010. Includes bibliographical references.

No description available.

Thesis (Ph. D.)--Florida State University, 2004. / Advisor: Dr. Alan G. Marshall, Florida State University, College of Arts and Sciences, Institute of Molecular Biophysics. Title and description from dissertation home page (viewed June 6, 2005). Document formatted into pages; contains xix, 146 pages. Includes bibliographical references (p. 107-125).

Thesis (M.S.) in Chemistry--University of Maine, 2006. / Includes vita. Includes bibliographical references (leaves 71-78).

No description available.

Duan Lifang. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 83-87). / Abstracts in English and Chinese. / Title Page --- p.i / Abstract (English) --- p.ii / Abstract (Chinese) --- p.iii / Acknowledgements --- p.iv / Table of Contents --- p.v / List of Tables --- p.vii / List of Figures --- p.viii / Symbols and Abbreviations --- p.x / Chapter CHAPTER 1 --- INTRODUCTION / Chapter 1.1 --- Mass spectrometry in biochemistry --- p.1 / Chapter 1.2 --- Electrospray ionization (ESI) --- p.2 / Chapter 1.3 --- Fourier transforms ion cyclotron resonance mass spectrometry (FTICR-MS) --- p.4 / Chapter 1.3.1 --- Ion motions --- p.5 / Chapter 1.3.2 --- Mass calibration --- p.7 / Chapter 1.3.3 --- Tandem mass spectrometry --- p.11 / Chapter 1.4 --- Sustained off-resonance irradiation collision-induced dissociation (SORI-CID) of peptide ions --- p.13 / Chapter 1.5 --- Outline of present work --- p.18 / Chapter CHAPTER 2 --- INSTRUMENTATION AND EXPERIMENTAL / Chapter 2.1 --- Fourier-trans form ion cyclotron resonance mass spectrometer --- p.19 / Chapter 2.1.1 --- Vacuum system --- p.19 / Chapter 2.1.2 --- Nanospray source --- p.23 / Chapter 2.1.3 --- Ion transfer system --- p.26 / Chapter 2.1.4 --- Infinity cell --- p.28 / Chapter 2.1.5 --- Data acquisition system --- p.29 / Chapter 2.2 --- Experimental --- p.29 / Chapter 2.2.1 --- Simple acquisition pulse program --- p.30 / Chapter 2.2.2 --- Tandem mass spectrometry (SORI-CID MS/MS) --- p.32 / Chapter CHAPTER 3 --- DISSOCIATION OF MODEL PEPTIDE IONS UNDER SORI-CID CONDITIONS / Chapter 3.1 --- Introduction --- p.35 / Chapter 3.2 --- Experimental --- p.37 / Chapter 3.3 --- Results and discussion --- p.41 / Chapter 3.3.1 --- "SORI-CID of XG3WG3X (where X 二 R, K and N)" --- p.41 / Chapter 3.3.2 --- SORI-CID of RGnWGnR (where n=l -5) --- p.46 / Chapter 3.3.3 --- SORI-CID of RG3XG3R (where X = D and E) --- p.48 / Chapter 3.4.4 --- SORI-CID of sequence isomers of RG5WG5R --- p.51 / Chapter 3.4 --- Conclusions --- p.56 / Chapter CHAPTER 4 --- EXACT MASS MEASUREMENTS OF THE PRODUCT IONS DERIVED FROM SORI-CID FTICR-MS / Chapter 4.1 --- Introduction --- p.57 / Chapter 4.2 --- Experimental --- p.60 / Chapter 4.3 --- Results and discussion --- p.61 / Chapter 4.3.1 --- Origin(s) of the mass measurement error --- p.63 / Chapter 4.3.2 --- Pressure effect on the cyclotron frequencies of trapped ions --- p.67 / Chapter 4.3.3 --- Modified internal lock-mass calibration method --- p.70 / Chapter 4.4 --- Conclusions --- p.79 / Chapter CHAPTER 5 --- CONCLUSIONS --- p.81 / REFERENCES --- p.83 / APPENDIX I The Proton affinity (PA) and the structural formulae of 20 α-amino acids --- p.88 / APPENDIX II Schematics of the proposed mechanisms of peptide dissociation under low-energy CID conditions --- p.89 / APPENDIX III Pulse programs for simple MS and MS/MS experiments --- p.92 / APPENDIX IV Schematics of the proposed mechanisms for the formation of y8+ ions from the singly protonated arginine- and lysine-containing peptides --- p.99

During the course of the systematic study, it was also discovered that doubly-protonated diarginated peptides containing multiple glutamic acid residues (E) (n>4) could suppress the backbone fragmentation of [M+2H]+· . Together with the results obtained from conformational searches, it was hypothesized that the interactions between carboxylic oxygens of E side chains and backbone amide hydrogens could stabilize the radical intermediate and thereby inhibiting the usual N-Calpha cleavages and H · loss from [M+2H]+·. / In order to ascertain the impacts of the structural features of polypeptide and oligosaccharide ions on the dissociation of these biomolecules under typical collision induced dissociation (CID) and electron capture dissociation (ECD) conditions, the dissociation patterns of even-electron precursor ions generated by protonation ([M+nH]n+)/metalation ([Metal+M]n+), odd-electron hydrogen-deficient precursor ions (M+·) generated by SORI-CID of [Cu(Tpy)M]2+ and odd-electron hydrogen-surplus precursor ions ([M+2H]+·) generated by ECD of [M+2H] 2+ were examined. It was found that backbone cleavages, with the generation of b/y and c/z ions, were dominant in the dissociation of [M+H]+ and [M+2H]+· respectively. Whilst in the dissociation of M+·, side chain loss reactions were the major fragments generated. For post translational modification (PTM)-containing peptides, the labile PTM groups were found to cleave preferentially in the dissociation of M+· and [M+H]+, but were found to be retained in the intact peptides and peptide fragments in the dissociation of [M+2H]+·. It is hypothesized that the different dissociation pathways is attributed to the different nature of radicals. Further to these, it was found that in the dissociation of oligosaccharides, similar cleavage patterns (glycosidic and cross-ring cleavages) were obtained regardless of the nature of the precursor ions (i.e. whether odd- or even-electron) and the ion activation conditions. / Chan, Wai Yi. / Adviser: T.W. Dominic Chan. / Source: Dissertation Abstracts International, Volume: 73-02, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 145-152). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

by Lim Che Lau. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 79-84). / Title Page --- p.i / Table of Contents --- p.ii / List of Tables --- p.iv / List of Figures --- p.v / List of Schemes --- p.vii / Acknowledgments --- p.viii / Abstract --- p.ix / Chapter CHAPTER 1: --- INTRODUCTION / Chapter 1.1. --- Historical Background --- p.1 / Chapter 1.2. --- FTICR with External Ion Source --- p.2 / Chapter 1.3. --- High Mass Analysis in FTICR --- p.4 / Chapter 1.4. --- Outline of Present Work --- p.7 / Chapter CHAPTER 2: --- INSTRUMENTATION AND EXPERIMENTAL / Chapter 2.1. --- Instrumentation --- p.8 / Chapter 2.1.1 --- Ion Source --- p.10 / Chapter 2.1.1.1. --- Liquid Secondary Ion Mass Spectrometry --- p.11 / Chapter 2.1.1.2. --- Electrospray Ionization --- p.12 / Chapter 2.1.2. --- Electrostatic Ion Focusing System --- p.15 / Chapter 2.1.3. --- ICR Analyzer Cell and Magnet --- p.18 / Chapter 2.1.4. --- Data Acquisition and Handling System --- p.22 / Chapter 2.2. --- Experimental --- p.22 / Chapter 2.2.1. --- Liquid Secondary Ion Mass Spectrometry --- p.22 / Chapter 2.2.2. --- Electrospray Ionization --- p.23 / Chapter 2.2.3. --- Nozzle-Skimmer Dissociation --- p.24 / Chapter 2.2.4. --- Sustained Off-Resonance Irradiation Collision- Induced Dissociation --- p.24 / Chapter 2.2.5. --- Data Acquisition and Processing --- p.27 / Chapter 2.2.6. --- Mass Calibration --- p.27 / Chapter CHAPTER 3: --- STRUCTURAL CHARACTERIZATION OF TERPYRIDINE-BASED POLYETHER DENDRIMERS AND THEIR IRON(II) METALLOCOMPLEXES BY LIQUID SECONDARY ION MASS SPECTROMETRY AND ELECTROSPRAY IONIZATION MASS SPECTROMETRY / Chapter 3.1. --- Introduction --- p.28 / Chapter 3.2. --- Sample Preparation --- p.29 / Chapter 3.3. --- Results and Discussion --- p.30 / Chapter 3.3.1. --- Liquid Secondary Ion Mass Spectrometry Studies --- p.30 / Chapter 3.3.1.1. --- Dendrimers --- p.30 / Chapter 3.3.1.2. --- Metallodendrimers --- p.41 / Chapter 3.3.2. --- Electrospray Ionization Mass Spectrometry Studies --- p.47 / Chapter 3.4. --- Conclusions --- p.53 / Chapter CHAPTER 4: --- STUDIES OF LANTHANIDE(III) PORPHYRIN- PHTHALOCYANINE HETEROLEPTIC SANDWICH COMPLEXES USING ELECTROSPRAY IONIZATION / Chapter 4.1. --- Introduction --- p.54 / Chapter 4.2. --- Results and Discussion --- p.55 / Chapter 4.2.1. --- Molecular Weight Determination --- p.57 / Chapter 4.2.2. --- Structural Elucidation --- p.65 / Chapter 4.2.3. --- Charge-Transfer Processes --- p.72 / Chapter 4.3. --- Conclusions --- p.76 / Chapter CHAPTER 5: --- CONCLUSIONS --- p.77 / References --- p.79