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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Synthesis of Isoguvacine, Paroxetine and Pseudoheliotridane

Tseng, Tze-Wei 19 August 2005 (has links)
Carbon skeleton of polysubstituted pyroglutamates with three contiguous asymmetric centers was built up in one base-induced coupling/cyclization reaction of £\-sulfonylacetamide with 2-bromo-2-propenoates and has been used as the key step in the formal synthesis of isoguvacine paroxetine, and psudoheliotridane.
psudoheliotridane
paroxetine
pyroglutamic acid
stepwise [3+2] annulation
isoguvacine

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