Global ETD Search

1	Approved medicinal products with potential companion diagnostic tests : An Inventory of the Swedish/European drug market Andersson, Katrin January 2023 (has links) The newly introduced regulation (EU) 2017/746 aims to make In Vitro Diagnostic Medical Devices (IVDMD), which include companion diagnostic tests (CDx), a widespread method of authorising medicinal products in the European market. However, European SmPCs (Summary of Product Characteristics) currently do not explicitly refer to the term or classify tests associated with medicinal products as CDx. This paper is the first to examine and classify tests for medicinal products currently authorised in Sweden as being potential CDx, under the definitions of the new regulatory paradigm. The aim is to serve as the foundation for future research. 141 medicinal products with potential associated CDx are identified in the database of the Swedish Medical Products Agency (MPA). These products are then classified under the major ATC (Anatomical Therapeutic Chemical) therapeutic areas to search for commonalities and patterns in their usage and are later examined in conjunction with the techniques they use. The results reveal that a majority are concentrated in the Antineoplastic and immunomodulating agents and Antiinfectives for systemic use therapeutic areas. The methods used by these tests reveal diversity among the test technique usage, including instances where multiple techniques comprise a single CDx product, which may focus on detecting several biomarkers. CDx Companion Diagnostic IVDMD In-vitro diagnostic medical devices Regulation (EU) 2017/746 Other Medical Biotechnology Annan medicinsk bioteknologi
2	Effects of white-tailed deer herbivory on a tallgrass prairie remnant Gooch, Scott 11 January 2010 (has links) A study was conducted to determine what impact high white-tailed deer (Odocoileus virginianus) densities were having on the native grasslands of a tallgrass: aspen forest tract embedded within an agro-urban setting. Due to excessive spring moisture, row-crops were unavailable the first year. Using microhistological fecal analysis to determine dietary composition, deer were assessed to be placing the site’s favoured native plant species at risk of extirpation. Measuring woody stem abundance and height along and near the prairie: forest ecotone, deer were found to restructure woody growth but not directly influence encroachment rates. Indirectly, however, deer facilitated forest encroachment and prairie degradation through seed dispersal, nitrogen deposition, gap-dynamics, and trampling. Comparing dietary composition to nutritional data, deer grazed to maximize fitness, selecting foods high in IVDMD, minimizing energy expenditure, and optimizing CP. High crop CP was offset by intensively grazing particular native plants. ADF was an effective nutritional marker, not AIA. white-tailed deer herbivory fecal analysis nutrient cycling forest encroachment foraging strategy disturbance index ADL nutritional markers row-crops grazing preferences gap dynamics seed propagation ecological fitness native plants forbs restoration ADF CP AIA NDF deer management ecological management IVDMD overabundance tallgrass energetics forbs
3	Effects of white-tailed deer herbivory on a tallgrass prairie remnant Gooch, Scott 11 January 2010 (has links) A study was conducted to determine what impact high white-tailed deer (Odocoileus virginianus) densities were having on the native grasslands of a tallgrass: aspen forest tract embedded within an agro-urban setting. Due to excessive spring moisture, row-crops were unavailable the first year. Using microhistological fecal analysis to determine dietary composition, deer were assessed to be placing the site’s favoured native plant species at risk of extirpation. Measuring woody stem abundance and height along and near the prairie: forest ecotone, deer were found to restructure woody growth but not directly influence encroachment rates. Indirectly, however, deer facilitated forest encroachment and prairie degradation through seed dispersal, nitrogen deposition, gap-dynamics, and trampling. Comparing dietary composition to nutritional data, deer grazed to maximize fitness, selecting foods high in IVDMD, minimizing energy expenditure, and optimizing CP. High crop CP was offset by intensively grazing particular native plants. ADF was an effective nutritional marker, not AIA. white-tailed deer herbivory fecal analysis nutrient cycling forest encroachment foraging strategy disturbance index ADL nutritional markers row-crops grazing preferences gap dynamics seed propagation ecological fitness native plants forbs restoration ADF CP AIA NDF deer management ecological management IVDMD overabundance tallgrass energetics forbs

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