While recent years have seen a rise of research in knowledge graph enrichedpre-trained language models(PLM), few studies have tried to transfer the work to the biomedical domain. This thesis is a first attempt to pre-train a large-scalebiological knowledge enriched language model (KPLM). Under the frameworkof CoLAKE (T. Sun et al., 2020), a general-use KPLM in general field, this study is pre-trained on PubMed abstracts (a large scale medical text data) andBIKG (AstraZeneca’s biological knowledge graph). We firstly get abstracts from PubMed and their entity linking results. Following this is to connect the entities from abstracts to BIKG to form sub-graphs. Such sub-graphs and sentences from PubMed abstracts are then sent to model CoLAKE for pre-training. By training the model on three objectives (masking word nodes, masking entity nodes and masking relation nodes), this research aims to not only enhancing model’s capacity on modeling natural language but also infusing in-depth knowledge. Later the model is fine-tuned on name entity recognition (NER) and relation extraction tasks on three benchmark datasets (Chemprot (Kringelumet al., 2016), DrugProt (form Text mining drug-protein/gene interactions sharedtask) and DDI (Segura-Bedmar et al., 2013)). Empirical results show that the model outperform state-of-the-art models relation extraction task on DDI dataset, with F1 score of 91.2%. Also on Drugprot and chemprot, this model shows improvement over baseline - scibert model.