This study focuses on the role of Information and communication technology (ICT) in support of effective knowledge management. Based on a comprehensive literature review, a knowledge management framework was developed for investigating the role of ICT in support of knowledge management. The framework not only centers on the dynamics of knowledge objects and processes, but also focuses on the impact of the internal knowledge management environment where organizational, managerial, structural, cultural and other related elements are intertwined and interplayed. Based on this research framework, two sets of hypotheses were proposed for testing: (a) whether ICT enables and facilitates conversions between knowledge objects and knowledge management processes, and (b) whether the internal knowledge management environment impacts the effective implementation of knowledge management projects. To test the hypotheses, a combination of qualitative and quantitative research methodologies including theoretical induction, continuous literature review, secondary data analysis, and the conduct of an online questionnaire survey and a case study was adopted in this study. The empirical findings were drawn from the secondary data analysis, case study and questionnaire survey. A questionnaire survey and a case study were conducted to obtain empirical data for testing and validating research hypotheses. To obtain a better understanding of current knowledge management best practices, secondary data were gathered and analyzed. In order to investigate the conversion processes of knowledge objects, an online survey was used to explore the experience, perceptions and opinions of respondents in the use of electronic resources at an individual level. To identify the factors that can determine success or failure in implementing knowledge management projects, a case study involving the pilot implementation of a knowledge portal was undertaken for collecting and analyzing empirical evidence from the field. The empirical findings confirm the ICT's enabling role in knowledge management. The results of this study further suggest that the conversion processes between data and information are fully supported by ICT, whereas the conversion processes between data and knowledge, and the conversion processes between information and knowledge are only partially supported by ICT. While knowledge codification and dissemination are increasingly supported by ICT, supportive technology for knowledge generation and application remains much less effective. The critical success factors impacting the implementation of knowledge management projects include organizational, structural, strategical, managerial, and cultural elements. These interlocking elements form the internal knowledge management environment in an organization. This study provides theoretical contributions by better understanding the nature of knowledge, the relationship between ICT and knowledge management, and the relationship between knowledge management and internal knowledge management environment. It also provides a contribution relevant to practitioners by developing a novel knowledge management framework, which can be used as a guideline of knowledge management efforts.