In the era of knowledge economy, human capital is the important capital which enterprise can rely on and maintain the competitiveness, and also the source of power for continuous innovation. To stimulate the working intention of knowledge worker is one of the important tasks for an enterprise to elaborate their human capital. This paper investigates the Biotechnology industry in order to understand that how the presentation of human capital in this knowledge intensive industry affects the innovation performance through the knowledge worker management. By the empirical data and statistic analysis in this paper, the findings are as below: I.The aspects of human capital are: the executives¡¦ direction ability of vision supervisors, the entrepreneurship of employees, the investment and exploitation in human capital, and excellent hire. II.The aspects of knowledge worker management are: the leadership of knowledge, the working styles with challenge, the plan of employees¡¦ development, organic designs of work, reasonable evaluation of performance, and the promotion of knowledge exchange. III.The aspects of innovation performance are: innovation of product and innovation of manufacture. IV.The influences of human capital on innovation performance. 1.The executives¡¦ direction ability of vision supervisors and the investment and exploitation of human capital both have significant positive effects on the innovation of products. Among which the investment and exploitation of human capital effects more than the executives¡¦ direction ability of vision supervisors does. 2.The entrepreneurship of employees has a significant negative effect on the innovation of products; the excellent hire has no significant effect. 3.The executives¡¦ direction ability of vision supervisors and the investment and exploitation of human capital both have significant positive effects on the innovation of manufacture. Among which the investment and exploitation of human capital effects more than the executives¡¦ direction ability of vision supervisors does. 4.The entrepreneurship of employees and excellent hire has no significant effect on the innovation of manufacture. V.The moderating effects on innovation performance from the interaction of human capital and knowledge worker management. 1.The interactions of excellent hire and leadership of knowledge, the working styles with challenge, and reasonable evaluation of performance have significant positive effect on innovation of products. 2.The interaction of the executives¡¦ direction ability of vision supervisors and organic designs of work has significant negative effect on innovation of products. 3.The interaction of the investment and exploitation of human capital and organic designs of work has significant positive effect on innovation of products. 4.The interaction of excellent hire and the plane of employees¡¦ development has significant positive effect on innovation of manufacture. 5.The interaction of the investment and exploitation of human capital and reasonable evaluation of performance has significant negative effect on innovation of manufacture. 6.The interaction of the executives¡¦ direction ability of vision supervisors and the promotion of knowledge exchange has significant positive effect on innovation of manufacture. 7.The interaction of the entrepreneurship of employees and the promotion of knowledge exchange has significant negative effect on innovation of manufacture.