Studium of the clinical impact of different forms of cardiac resynchronization therapy by patients with chronic heart failure MUDr. Lucie Burianová ABSTRACT: Introduction: Biventricular (BiV) pacing decreases mortality and improves quality of life of patients with severe heart failure. Haemodynamic and short time clinical studies suggest that isolated leftventricular pacing could have the same effect. Aims: Compare the effect of BiV and leftventricular pacing by subjects with dilated cardiomyopathy and severe heart failure with the attention to signs of dyssynchrony and remodelation of the left chamber. In methodical substudy compare the results of left chamber volumes and ejection fraction (EF LK) measured by CT angiography and 2-dimensional echocardiography with use of contrast agent (K-ECHO). Methods: Patients indicated for cardiac resynchronization therapy were randomized for either BiV or leftventricular pacing. After implantation of the device they were examinated clinically and by echocardiography every 3 months in the period of one year. Four years from the onset of the study the major adverse events in both groups were evaluated. The results of left chamber volumes and EF LK measured by K-ECHO and CT angiography were compared. Results: We enrolled 33 patients. We found clinical improvement in both...

Studium of the clinical impact of different forms of cardiac resynchronization therapy by patients with chronic heart failure MUDr. Lucie Burianová ABSTRACT: Introduction: Biventricular (BiV) pacing decreases mortality and improves quality of life of patients with severe heart failure. Haemodynamic and short time clinical studies suggest that isolated leftventricular pacing could have the same effect. Aims: Compare the effect of BiV and leftventricular pacing by subjects with dilated cardiomyopathy and severe heart failure with the attention to signs of dyssynchrony and remodelation of the left chamber. In methodical substudy compare the results of left chamber volumes and ejection fraction (EF LK) measured by CT angiography and 2-dimensional echocardiography with use of contrast agent (K-ECHO). Methods: Patients indicated for cardiac resynchronization therapy were randomized for either BiV or leftventricular pacing. After implantation of the device they were examinated clinically and by echocardiography every 3 months in the period of one year. Four years from the onset of the study the major adverse events in both groups were evaluated. The results of left chamber volumes and EF LK measured by K-ECHO and CT angiography were compared. Results: We enrolled 33 patients. We found clinical improvement in both...

This thesis deals with professional liability insurance. It discusses professional liability insurance, including specifics relating to this insurance. The thesis analyzes the framework agreement concluded by selected professional associations with insurance companies. It examines the situation on the Czech market in terms of this insurance product.

The topic of this thesis is the position and activities of the Czech Medical Chamber. Its aim is to analyze the role and purpose of this professional chamber in the Czech Republic. I have chosen this particular topic because I mean that although the self- government of professional associations, especially the Czech Medical Chamber, belongs to very important institutes of the legal order of the Czech Republic; the literature addresses this issue only marginally. The next reason for my research is the fact, that just the Czech Medical Chamber is very questionable professional chamber. The thesis is composed of five chapters; each of them describes particular aspects of Czech Medical Chamber (CMC). Chapter One is introductory and is trying to explain the notions self-government and public corporation. The last part of this chapter deals the political, economic and sociological aspects of the CMC. Chapter Two consists of two parts. Part One surveys historical development of the CMC from year 1891, when the Habsburg monarchy issued a law on the establishment of medical chambers, to the present. Part Two look at medical chambers in other countries of Central Europe and endeavours to compare these organizations. Chapter three is subdivided into two parts. Part One focuses on functions of the CMS and...

- Position and activities of the Czech Bar Chamber The topic of my thesis is "Position and activities of the Czech Bar Chamber". The purpose of the thesis is to analyze the role, importance and functioning of the professional chamber which associates over of 12 000 attorneys. I have chosen this particular topic as I think the available literature dealing with professional chambers, particularly the Czech Bar Association (hereinafter CBA) is not up-to- date and does not comprehensively cover the current status of this institution. In addition to the descriptive passages the thesis includes statistical data analysis, reflections on the current state of the CBA and its possible transformation. The thesis is composed of five chapters; the first chapter is a brief introduction to the issue of self-government. It covers what this term means, explains the dividing of self- government and focuses on describing the related terms. The second chapter provides an insight into the history of attorney self-government. Its formation and development is presented including the production of relevant legislation from the late 19th century through the period of the first Republic of Czechoslovakia, to the era of the destructive socialist regime until the post-revolutionary renaissance of freedom of advocacy. The key...

This diploma thesis deals with professional liability insurance in the Czech Republic. The first chapter focuses on a general description of the insurance and its construction, the basic classification of legal liability and explanation of the types of insurance. The following chapter closely examines the status of professional associations and analyzes the framework agreement concluded by the selected associations. Another part is focused on the professional liability insurance of insurance intermediaries and independent loss adjusters. The last chapter describes the progression and current situation of professional liability insurance, focuses on the current possibilities of arranging insurance and presents selected insurance products.

The thesis is about professional liability insurance, focused primarily on legal professions. The first part describes general liability insurance, then the thesis is focused on characteristics and specific features of professional liability insurance. The thesis also analyzes legal requirements for insurance of selected professions and significance of professional associations in professional liability insurance. In conclusion, it examines availability of professional liability insurance products on the Czech insurance market.

Aby bylo možné charakterizovat atmosfericky citlivé vzorky ve vysokofrekvenčním elektronovém paramagnetickém rezonančním spektrometru (z angl. high-frequency electron paramagnetic resonance spectrometer, HF-EPR), je potřebné mít vakuový transportní systém. Cílem této práce je navrhnout a vyvinout tento vakuový přepravní systém, který umožní tuto přepravu. Vakuový systém, který se skládá z mobilního vakuového kufru, držáku palety a přechodové komory, byly navrženy, sestaveny a testovány. Bylo dosaženo tlaku 4,3 10^{-10}mbar, což zajistí inertní podmínky pro transport vzorků. Byl proveden transport vzorku ze systému ultravysokého vakua (UHV) do HF-EPR spektrometru. Kontaminace testovacích vzorků byla charakterizována pomocí rentgenové fotoelektronové spektroskopie. Bylo zjištěno, že nedochází téměř k žádné detekovatelné kontaminaci, pokud je vzorek přepravován pomocí vakuovém systému méně než 16 hodin. Bylo navrženo rozšíření pro přepravu vzorků z rukavicového boxu a paletky pro grafen, ale jejich výroba dosud nebyla provedena. Vyvinutý vakuový systém je plně funkční a poskytuje alternativu ke komerčně dostupným produktům, a proto bude dále používán při zkoumání vzorků citlivých na atmosféru v laboratořích CEITEC Nano.

Cardiovascular diseases account for the majority of deaths both worldwide and in the Czech Republic. Main factors contributing heart disease development, aside age and sex, are obesity, high blood pressure and high blood cholesterol and triglyceride levels. Spontaneously hypertensive rat (SHR) was developed and used for search of genetic determinants of these traits. This commonly used rat model develops hypertension, dyslipidemia, and insulin resistance naturally which is caused by aberrant Cd36 fatty acid translocase gene. Previous studies have shown that rescue of Cd36 performed in the transgenic SHR-Tg19 strain enhances cardiac beta-adrenergic system, slightly increases heart mass and leads to higher susceptibility to arrhythmias. The present thesis had two main aims: 1) To investigate whether and how a transgenic rescue of Cd36 in SHR affects protein composition, mitochondrial function and activity of selected metabolic enzymes of the heart. 2) To study the expression and distribution of selected components of beta-adrenergic signaling system in lipid raft isolated form membranes using the TX-100 detergent. We set to compare two commonly used proteomic approaches, 2D electrophoresis with MALDI-TOF mass spectrometry and label-free LC-MS. The results did not reveal any overlap between...

Trace element bioaccumulation in benthic organisms is important part of aquatic environment pollution research, since water and sediment analysis itselfs do not provide significant information about bioavailability of contaminants and the results mostly shows just current pollution at the time of sampling. This study focuses on urban streams contamination which are currently significant source of trace elements. Botic stream was chosen as exemplary, because it is affected by many combined sewer system overflows which are sources of contamination in times of heavy rain and flood. Load several sampling took place on 10 stream sites during the year of 2012. This thesis deals with 11 trace elements concretelly Cd, Co, Cr, Cu, Hg, Ni, Zn, As, Fe, Pb and Al. Trace elements were assessed in both benthic organisms and sediment. As well taxons were selected from benthic organisms, which are widely found at any time of the reference year: caddisflies of family Hydropsychidae, leeches Erpobdella sp. and mayflies of Baetidae family. Sediment analysis included sequential extraction which divided trace elements into 4 fractions according to mobility. Based on the results, bioavailability was assessed on observed elements and correlation between concentration in bethos and sediment was tested. Finally, impact of...