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Biochemical and immunological studies of cell surface antigens on lymphoblastoid cells.Ng, Wai-shing, January 1977 (has links)
Thesis--Ph. D., University of Hong Kong, 1978. / Typescript.
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Roles of TLR5 and ICOS on the human allogenic CD40-activated B cell-induced CD4hiCD25+ regulatory T cellsChan, Ping-lung., 陳秉隆. January 2011 (has links)
published_or_final_version / Paediatrics and Adolescent Medicine / Doctoral / Doctor of Philosophy
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Development and evaluation of avian influenza H5 virus antigen captureELISAs for use in Avian influenza diagnosis潘慧敏, Poon, Wai-man. January 2003 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Production of transgenic plant-derived vaccines via plastid transformation technologyLee, Yuk-ting., 李玉婷. January 2004 (has links)
published_or_final_version / abstract / toc / Botany / Master / Master of Philosophy
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Purification and biological properties of excretory/secretory antigensfrom trichinella spiralis梁健明, Leung, Kin-ming, Rayman. January 1995 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
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Biochemical and immunological studies of cell surface antigens on lymphoblastoid cellsNg, Wai-shing, 吳偉成 January 1977 (has links)
published_or_final_version / Microbiology / Doctoral / Doctor of Philosophy
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Investigation into the immunogenicity of human leukocyte antigen mismatches in kidney transplantationKosmoliaptsis, Vasilis January 2011 (has links)
No description available.
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Synthesis and oxidation studies of sulfur containing inhibitors for human leukocyte elastase : (2) synthesis of cyclic peptide analogs for tissue factor pathway inhibitor (TFPI) : Part 2 synthesis and evaluation of aziridinecarboxylic acid analogs as a new family of cysteine proteinase inhibitorsYamamoto, Masaru 08 1900 (has links)
No description available.
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Synthesis of potent antitumor congeners and prodrugs of quinonoid compounds and alkaloidsLambropoulos, John 05 1900 (has links)
No description available.
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A study of MRP1-drug interactions : identification of the drug binding site(s)Daoud, Roni N. January 2000 (has links)
Over-expression of either P-gp1 and/or MRP1 in tumor cell lines confers resistance to structurally diverse anti-cancer drugs. Although the role of these two proteins in clinical drug resistance remains to be confirmed, the use of Pgp1-specific inhibitors in combination with standard anti-cancer drugs have demonstrated significant improvement in clinical response. However, evidence exists that reversal of P-gp1 alone is not sufficient. Therefore, while no drugs are currently available that can efficiently reverse MRP1 drug efflux in tumor cells, there is an urgent need to develop MRP1-specific blockers. In an effort to gain a better understanding of MRP1-drug interactions and to identify sequences within MRP1 that interact directly with drugs, we developed two structurally diverse photosensitive drug analogues, a quinoline-based compound (IACI) and a xanthone-derivative (IAARh123). Both compounds photolabeled MRP1 and showed a direct and specific interaction with the protein at physiologically relevant sites. Initial mapping of photolabeled sequences in MRP1 (Chapters 2 and 3), identified multiple IACI- or IAARh123-photolabeled peptides (∼4--7 kDa) derived from both the N-terminal (MSD0+MSD1+NBD 1) and C-terminal (MSD2+NBD2) domains of MRP1. A subsequent study (Chapter 4), using MRP1 variants with hemagglutinin (HA) epitopes inserted at eight different locations, led to a higher resolution mapping of the previously identified IACI- or IAARh123-labeled peptides. Specifically, two photolabeled peptides (∼6--7 kDa), derived from variants with insertions at positions 574 and 1222, were immunoprecipitated with anti-HA monoclonal antibody. Based on the location of the HA epitopes in the latter variants together with molecular masses of the two peptides, the photolabeled amino acid residues were localized to MRP1 sequences encoding transmembranes 10 and 11 of MSD1 and transmembranes 16 and 17 of MSD 2. Interestingly, the same sequences were photolabeled with both
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