In recent years, due to advances in semiconductor technology and mature integrated circuit design, complex signal processing equipment is beginning to be replaced by the integrated circuit. This paper presents an integrated circuit programmable frequency generator for open-loop resonator application and its evaluation. It can eventually replace the conventional discrete component system and be used to find the resonance frequency shift for the readout of micro-balances or similar devices. The oscillator provides an analog tuning input to set the coarse center frequency and bit resolution, and uses a digital input to control the frequency sweep. Calculating the resonance frequency difference between the active balance and a passive reference can mitigate some environmental effects on the resonator (e.g. temperature). The generator circuit is designed using Synopsys¡¦ HSPICE and Cadence's Spectre to perform circuit simulation. The circuit is implemented by Taiwan Semiconductor Manufacturing Company in 0.35 £gm 2-poly 4-metal CMOS process technology. The potential detection precision of a micro-balance using the forward generator is assessed by connecting test chips to an evaluation PCB with commercial piezo crystals providing a known resonance frequency for testing. National Instruments¡¦ LABVIEW is used to record the data output, and MATLAB to analyze the results. A minimum detection accuracy of 1 kHz is demonstrated with this setup.