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Statistical analysis on the effect of splenectomy-induced thrombosisHsu, Chung-Hsien 25 July 2000 (has links)
In this work, it is of interest to study the effects of
thrombocytosis and microvascular anastomosis to that of vascular
thrombosis. Here the splenectomy is used to the experimental
subjects to have caused thrombocytosis first and later have the
microvascular anastomsis on the divided vessel. Observations on
different variables which may be related to vascular thrombosis
are obtained during the three stages of the experiments, there
are pre-splenectomy, post-splenectomy but before vascular
division, and after the vascular anastomsis. These variables
include platelet number, RBC count, Nitric oxide(nitrite and
nitrate), femoral artery perfusion unit, hematocrit,
reticulated-platelet number, and activated-platelets(p-selectin,
CD62p). The experimental units are divided into thrombocysis
group and control group. Basic statistical analysis are performed
first to see the differences between the two groups for the above
mentioned variables, and later try to use the profile analysis in
multivariate analysis to understand the changes of these
variables in different stages as well as their possible
relationships with the cause of vascular thrombosis. Finally,
classical regression and robust regression analysis for finding
outliers are also used to see whether certain characteristics of
those outliers have something to do with vascular thrombosis.
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