There is evidence of false recognition (FR) driven by orthographic similarities within languages (Lambert, Chang, & Lin, 2001; Raser, 1972) and some evidence that FR crosses languages (Parra, 2013). No study has investigated whether FR based on orthographic similarities occurs for unknown words in an unknown language. This study aimed to answer this question. It further explored whether FR based on orthographic similarities is more likely in a known (English) than in an unknown (Spanish) language. Forty-six English monolinguals participated. They studied 50 English and 50 Spanish words during a study phase. A recognition test was given immediately after the study phase. It consisted of 40 Spanish and 40 English words. It included list words (i.e., words presented at study); homographs (i.e., words not presented at study, orthographically similar to words presented at study); and unrelated words (i.e., words not presented at study, not orthographically similar to words presented at study). The LSD post-hoc test showed significant results supporting the hypothesis that false recognition based on orthographic similarities occurs for words in a known language (English) and in an unknown language (Spanish). Further evidence was provided by the LSD post-hoc test supporting the hypothesis that false recognition based on orthographic similarities was more likely to occur in a known language than an unknown language. Results provided evidence that the meaning and orthographic form are used when information is encoded thereby influencing recognition decisions. Furthermore, these results emphasize the significance of orthography when information is encoded and retrieved.