Based on the author's Thesis (doctoral--Oxford). / Description based on print version record. Includes bibliographical references and index.

Affektfokuserad psykoterapi är på frammarsch i västvärlden och forskningen indikerar goda resultat. Vidare är handledning ett viktigt moment för många yrkesgrupper, inte minst för psykoterapeuter. Det finns mycket forskning om handledning i allmänhet, däremot finns det inte så mycket forskning om effekter av grupphandledning. Syftet med denna studie var dels att undersöka vad en teoretisk utbildning samt metodhandledning i grupp i affektfokuserad psykoterapi kommit att betyda för fem deltagande psykoterapeuter, dels att se på vilket sätt de använder sig av affektfokuserad psykoterapi. Metoden som använts i studien har en kvalitativ ansats och den baseras på semistrukturerade intervjuer. Resultatet visar att metodhandledningen var mycket värdefull. Samtliga informanter sade sig vara nöjda med metodhandledningen, även om den också många gånger var känslomässigt utmanande. Alla sade sig vara intresserade av affektfokuserad psykoterapi, och hade stor nytta av metodens olika inslag i mötet med patienter. Däremot använde sig ingen av metoden på ett renodlat sätt i sin kliniska verksamhet. / Affect-focused psychotherapy is on the march in the western world and the research indicates good results. Furthermore, supervision is a valuable element for many professionals, especially for psychotherapists. There is much research on supervision in general, however, there is not much research on the effects of group supervision. The purpose of this study was to investigate what the theoretical training and method group supervision in affect-focused psychotherapy have come to mean for the five participating psychotherapists, and to see how they make use of affect-focused psychotherapy. The method used in the study has a qualitative approach and it is based on semi structured interviews. The results show that method supervision was very important. All respondents said they were satisfied with the method supervision, although many times it was emotionally challenging. All said they were interested in affect-focused psychotherapy, and had great use of the method and its various elements with their patients. However none used the method in a pure manner in their clinical activities.

Mitochondrial diseases are caused by gene mutations in either mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) and they are among one of the most common forms of inherited disorders. It is estimated that 1 out of every 5000 individuals will develop a mitochondrial disease in their lifetime. Due to the crucial and widespread functionality of mitochondria in human cells, prolonged diseases of the mitochondria affect cells of the brain, heart, liver, muscles and kidneys and can lead to multi-organ failure in some patients. Inherited or acquired mitochondrial diseases can present at any stage of life, affecting both children and adults. Since its discovery, the mitochondrial genome has been analyzed and sequenced with increasing ease and this process has helped recognize various mitochondrial disorders as the root of genetic diseases. This paper will explore the unique properties of the mitochondrion and its genome, examine the relationship between mtDNA and some common myopathies such as Leigh syndrome (LS) or maternally inherited Leigh syndrome (MILS), mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) in order to explore commonalities and differences in their inheritance patterns and their effect on mitochondrial function. Although studies have shown that these conditions generally affect the process of oxidative phosphorylation in mitochondria, because of the wide variety of presentations of this disease, further research is needed to understand the different etiologies, as well as to explore novel therapies to treat them.

Thesis (M.A.)--Colgate Rochester Divinity School/Bexley Hall/Crozer Theological Seminary, 1997. / Abstract. Includes bibliographical references (leaves 59-62).

Thesis (M.A.)--Colgate Rochester Divinity School/Bexley Hall/Crozer Theological Seminary, 1997. / Abstract. Includes bibliographical references (leaves 59-62).

Thesis (Ph. D.)--Florida State University, 2005. / Advisor: S. E. Gontarski, Florida State University, College of Arts and Sciences, Dept. of English. Title and description from dissertation home page (viewed Jan. 24, 2006). Document formatted into pages; contains v, 159 pages. Includes bibliographical references.

Thesis (M.A.)--Colgate Rochester Divinity School/Bexley Hall/Crozer Theological Seminary, 1997. / Abstract. Includes bibliographical references (leaves 59-62).

Mitochondrial disorders are considered to be the most common cause of metabolic abnormalities in the paediatric neurology population (Zeviani et al., 1996). These authors reported that the phenotypes observed in 25-30% of the paediatric patients in their neurology clinics were due to a mitochondrial aetiology. The genetic aetiology in an equivalently affected paediatric population in South Africa is currently unknown. This study investigated the possibility that reported mutations could account for the mitochondrial phenotypes observed in the South African population. It focussed on the most frequent paediatric mitochondrial disorders namely: Leigh Syndrome (LS), mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), and myoclonic epilepsy and ragged red muscle fibres (MERRF). A clinically well characterised group of 25 patients with mitochondrial disorders was included in this study. The molecular analysis of the mitochondrial genome was initially based on a restriction fragment length polymorphism (RFLP) screening strategy for the ten most common mitochondrial DNA (mtDNA) mutations associated with the above¬mentioned three disorders. However, during the study the mutation analysis strategy was modified to a sequencing strategy as this provided more information than the RFLP approach. The modified sequencing strategy extended the study to incorporate fifteen additional mtDNA mutations, associated with other mitochondrial disorders, and individuals included in the study were thus investigated for the presence of 25 mtDNA mutations. Moreover, the modified strategy provided additional information of the regions encompassing the reported mutations. A single patient was observed to harbour the reported A3243G MELAS mutation. This mutation was noted to be heteroplasmic in the proband and two of her maternal relatives. None of the other 24 reported mutations were observed in this patient population. One novel mtDNA alteration in the tRNALeu(UUR) gene was observed in a single patient, although the pathogenicity of this mutation remains to be investigated. Novel and reported polymorph isms, some of which are associated with specific haplogroups, were also observed when comparing sequencing data against the Cambridge reference sequence. The data generated during this study contributed towards the understanding of the uniqueness of the South African population in the global context. This was apparent from the fact that only one of the reported mutations was observed in our patient population who were clinically well characterised and displayed phenotypes similar to those reported internationally. Results form this study underlined the complexity of mitochondrial disorders and argues in favour of whole mitochondrial genome sequence information to be used for diagnostic purposes. Moreover, the results confer with the hypothesis that novel mitochondrial mutations may account for the majority of mitochondrial phenotypes observed in the South African population. / Dissertation (MSc (Human Genetics))--University of Pretoria, 2007. / Genetics / unrestricted

According to traditional accounts, following the premature deaths of Keats, Shelley, and Byron in the 1820s, literature in England fell into a sort of slumber until the late 1830s and early 1840s, when a new generation-a generation we now call the Victorians-came on the scene. Literary scholarship has tended to ignore this period of slumber as an uninteresting gap between the two dynamic movements of Romanticism and Victorianism. It was during this transitional period, however, that Leigh Hunt, one of the most radical of Romantic figures, wrote and staged A Legend of Florence (1840) in an attempt to stimulate a literary revival. Hunt's play reasserts the radical philosophies that defined his younger days, when as the central figure of the "Cockney School" he had drawn other radical writers such as Keats and Shelley into his circle. These philosophies included the primacy of literature, political radicalism, sexual liberation, and group authorship. By writing a play in 1840 that reasserted these ideals, Hunt hoped to gather a new coterie following reminiscent of the Cockney School. Responses to the play from Hunt's younger Victorian contemporaries, however, demonstrate how Hunt's once radical "Cockney" ideals had now become relatively safe. The nostalgic fondness with which A Legend of Florence was greeted therefore highlights how in 1840 Romanticism was in the process of being absorbed into Victorian philosophy and aesthetics.

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