Pesquisas sobre o transtorno obsessivo-compulsivo (TOC) que reunem pacientes em subgrupos homogêneos a partir de dimensões de sintomas, e as que investigam sua validade utilizando métodos genéticos, de neuroimagem e de resposta terapêutica, têm produzido resultados de valor heurístico. Em particular, a dimensão de colecionismo mostrou ser a mais distinta quanto às características neurobiológicas e a mais associada à pior resposta aos tratamentos farmacológicos e psicoterápicos. Paralelamente, novos métodos de tratamento neurocirúrgico para os casos mais refratários e graves tem sido testados no TOC, atingindo mais eficácia e segurança. Entretanto, não há registro na literatura de uma investigação sistemática da relação entre a presença de dimensões de sintomas antes das cirurgias e o resultado clínico. O objetivo deste estudo foi investigar se dimensões de sintomas, em particular o colecionismo, poderiam influenciar a resposta terapêutica às neurocirurgias límbicas para o tratamento do TOC. Informações de 77 pacientes submetidos à cirurgias ablativas para o tratamento de TOC em três centros de pesquisa das cidades de São Paulo (Brasil, n=17), Boston (EUA, n=37) e Estocolmo (Suécia, n=23) foram analisadas utilizando a Dimensional Yale-Brown Obsessive-Compulsive Scale (DYBOCS; São xvi Paulo) ou a Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC; Boston e Estocolmo) para a estratificação em dimensões de sintomas, e os escores YBOCS para avaliações de resultado clinico. Após os procedimentos, houve uma diminuição média de 34,2% nos escores YBOCS (IC 95% de 27,2% a 41,3%), com um tempo de seguimento médio de 34,8 meses, sem diferença significativa entre os centros de pesquisa ou em relação ao tipo de cirurgia (capsulotomia, São Paulo e Estocolmo; cingulotomia, Boston). Pacientes com dimensão de colecionismo apresentaram pior resposta ao tratamento (redução média dos escores YBOCS de 22,70% [DP = 32,23] para pacientes com colecionismo versus 41,60% [DP = 25,99] para pacientes sem colecionismo, p=0,006). Pacientes com dimensão de pensamentos proibidos também revelaram pior resposta ao tratamento (redução média dos escores YBOCS de 30,10% [DP = 29,61] para pacientes com pensamentos proibidos versus 51,33% [DP = 32,74] para pacientes sem pensamentos proibidos, p=0,033), mas este efeito dependeu da co-ocorrência das dimensões de pensamentos proibidos e colecionismo. Ao se utilizar um modelo de análise de variância (ANOVA), apenas a influência negativa do colecionismo se manteve: a redução média dos escores YBOCS em todos os pacientes foi de 13 pontos, mas em pacientes com colecionismo essa redução foi de 7 pontos (p=0,002). Concluindo, a presença da dimensão de colecionismo no momento pré-operatório associou-se à redução da melhora clínica decorrente da intervenção neurocirúrgica / Research on obsessive-compulsive disorder (OCD) using symptom dymension strategies to identify more homogeneous patient subgroups, coupled with genetic, neuroimaging, and treatment outcome studies, has produced results of heuristic value. In particular, the hoarding dimension has more distinct neurobiological characteristics and has been associated with worse response to pharmachological and psychoterapeutic treatments. At the same time, the most severe and treatment refractory cases of OCD have been treated with novel neurosurgical techniques, with better efficacy and safety profiles. However, the association between symptom dimensions prior to surgery and the treatment outcome after the limbic procedure has not been sistematically investigated in the literature so far. The objective of this study was to investigate if symptom dymensions, in particular hoarding, could influence treatment outcome of limbic neurosurgeries for OCD. Information on 77 patients that underwent limbic ablative procedures for OCD from three research centers at Sao Paulo (Brazil, n=17), Boston (USA, n=37), and Stockholm (Sweden, n=23) were collected and analyzed. Symptom stratification was obtained using the Dimensional Yale-Brown Obsessive-Compulsive Scale (DYBOCS; Sao Paulo) or the Yale-Brown xix Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC; Boston and Stockholm) and treatment outcome was defined using YBOCS scores. Mean YBOCS scores reduced 34.2% after surgery (CI 95% = 27.2% to 41.3%) with a mean follow-up of 34.8 months. There was no significant difference among centers or in relation to the method of surgical intervention (capsulotomy, Sao Paulo and Stockholm; cingulotomy, Boston). Patients with hoarding symptoms had worse response to treatment (mean YBOCS reduction of 22.70% [SD = 32.23] for hoarding patients vs. 41.60% [SD = 25.99] for patients without hoarding symptoms, p=0,006). Patients with forbidden thoughts symptoms apparently also had worse response to treatment (mean YBOCS reduction of 30.10% [SD = 29.61] for patients with forbidden thoughts vs. 51.33% [SD = 32.74] for patients without this symptom dymension, p=0,033), but this effect proved dependent on the co-occurence of forbidden thoughts with hoarding dymensions. Indeed, using an analisys of variance model (ANOVA) only the negative influence of the hoarding dymension remained: patients without hoarding had a mean YBOCS redution of 13 points, while in patients with hoarding symptoms the mean reduction was of 7 points (p=0.002). In conclusion, the pre-operative presence of the hoarding dymension was associated with worst clinical outcome after the neurosurgical procedures

Charles University of Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medicinal Sciences Student: Bc. Veronika Hončová Supervisor: Doc. MUDr. Josef Herink, DrSc. Consultant: MUDr. Jela Hrnčiarová Title: Signs of the temporolimbic dysfunction in gamblers Background: The aim of this thesis was to determine whether pathological gamblers exhibit symptoms related to epileptic spectrum disorder. Methods: To investigate, symptoms of the temporolimbic dysfunction were examined by means of the structured questionnaires CPSI (Complex Partial Symptoms Inventory) and LSCL-33 (Limbic System Checklist-33). Mann-Whitney U test and Spearman's correlation coefficient were used for statistical evaluation. Results: The mean score in the questionnaire CPSI of gamblers was 38,9 points, which is an abnormal score. With the questionnaire LSCL-33, the mean score of 21,5 points, corresponds to suspected findings. From the mean results it can be concluded that pathological gamblers may have a higher incidence of the symptoms of the temporolimbic dysfunction. When comparing the groups of gamblers with smokers, it was evaluated that in the questionnaire CPSI was a statistically significant difference between the appearances of symptoms of epileptic spectrum disorder, while it was not in the...

This dissertation discusses an implementation of a design, control and motion planning for a novel extendable modular redundant robotic manipulator in space constraints, which robots may encounter for completing required tasks in small and constrained environment. The design intent is to facilitate the movement of the proposed robotic manipulator in constrained environments, such as rubble piles. The proposed robotic manipulator with multi Degree of Freedom (m-DOF) links is capable of elongating by 25% of its nominal length. In this context, a design optimization problem with multiple objectives is also considered. In order to identify the benefits of the proposed design strategy, the reachable workspace of the proposed manipulator is compared with that of the Jet Propulsion Laboratory (JPL) serpentine robot. The simulation results show that the proposed manipulator has a relatively efficient reachable workspace, needed in constrained environments. The singularity and manipulability of the designed manipulator are investigated. In this study, we investigate the number of links that produces the optimal design architecture of the proposed robotic manipulator. The total number of links decided by a design optimization can be useful distinction in practice. Also, we have considered a novel robust bio-inspired Sliding Mode Control (SMC) to achieve favorable tracking performance for a class of robotic manipulators with uncertainties. To eliminate the chattering problem of the conventional sliding mode control, we apply the Brain Emotional Learning Based Intelligent Control (BELBIC) to adaptively adjust the control input law in sliding mode control. The on-line computed parameters achieve favorable system robustness in process of parameter uncertainties and external disturbances. The simulation results demonstrate that our control strategy is effective in tracking high speed trajectories with less chattering, as compared to the conventional sliding mode control. The learning process of BLS is shown to enhance the performance of a new robust controller. Lastly, we consider the potential field methodology to generate a desired trajectory in small and constrained environments. Also, Obstacle Collision Avoidance (OCA) is applied to obtain an inverse kinematic solution of a redundant robotic manipulator.

Psychopathy is a severe personality disorder associated with a range of affective, interpersonal, and behavioural abnormalities. Evidence suggests that psychopaths show marked deficits in processing emotional information, although it is unclear whether they also show more general deficits in error monitoring, attention allocation and response control. It is also unclear whether any variation in neurophysiological performance is also reflected in subclinical populations. In this thesis, event-related potentials (ERPs) were used to examine these issues and involved two separate samples. The first included incarcerated offenders with a range of scores on the Hare Psychopathy Checklist –Revised (PCL-R) and non-offender (staff) controls. The second included a large group of healthy undergraduate males with a full range on scores on the Self-Report Psychopathy Scale (SRP-III). Error monitoring was examined in both samples using a standard letter-flanker task and a modified version of the task in which faces with angry or fearful expressions were used instead of the usual letter stimuli. In general, psychopathy in both samples was associated with attenuated ERN amplitudes on the face flanker task only. Source modeling of the ERN indicated that, while the ERN is generally modeled as having a dipole in the ACC, the psychopath group showed no evidence of ACC activity in this region in conjunction with face-flanker errors. These data suggest that the affect-based neurophysiological deficits associated with psychopathy in the clinical range are observed in a graduated fashion among subclinical samples. Inhibitory control processes were also examined in the incarcerated group using the inhibitory N2 and anteriorized P3 as indices of inhibitory processes evident in correctly withholding prepotent response tendencies on a Go-NoGo task. Despite the common assumption that poor inhibitory control is a central aspect of psychopathy, there was no sign that those at higher levels of psychopathy showed any inhibitory control problems and they produced a robust NoGo N2 and P3. In fact, there were signs that the incarcerated offenders who were low on psychopathy were more likely to produce diminished inhibitory-related components. Finally, years of controversy regarding attention allocation deficits in psychopathy was addressed by collecting standard P3 components during a traditional visual oddball task in the university sample. Behavioural response and P3 amplitudes were unrelated to psychopathy. However, consistent with data from incarcerated samples, higher scores on psychopathy were associated with larger amplitude P2 and N5 responses to target relative to nontarget stimuli, again suggesting some continuity with respect to a distinct, although not necessarily deficient, attentional style at subclinical levels of psychopathy. In general, across these four data sets, the only clear evidence of impaired processing involved a reduced error-monitoring response during the face-flanker task when emotional stimuli formed the basis of the required discrimination and this reduced response was found to vary with the degree of psychopathy even within a subclinical range. These findings support a model of psychopathy involving limbic and paralimbic structures rather than a general reduction in neural function affecting error monitoring, attention allocation and response control.

Psychopathy is a severe personality disorder associated with a range of affective, interpersonal, and behavioural abnormalities. Evidence suggests that psychopaths show marked deficits in processing emotional information, although it is unclear whether they also show more general deficits in error monitoring, attention allocation and response control. It is also unclear whether any variation in neurophysiological performance is also reflected in subclinical populations. In this thesis, event-related potentials (ERPs) were used to examine these issues and involved two separate samples. The first included incarcerated offenders with a range of scores on the Hare Psychopathy Checklist –Revised (PCL-R) and non-offender (staff) controls. The second included a large group of healthy undergraduate males with a full range on scores on the Self-Report Psychopathy Scale (SRP-III). Error monitoring was examined in both samples using a standard letter-flanker task and a modified version of the task in which faces with angry or fearful expressions were used instead of the usual letter stimuli. In general, psychopathy in both samples was associated with attenuated ERN amplitudes on the face flanker task only. Source modeling of the ERN indicated that, while the ERN is generally modeled as having a dipole in the ACC, the psychopath group showed no evidence of ACC activity in this region in conjunction with face-flanker errors. These data suggest that the affect-based neurophysiological deficits associated with psychopathy in the clinical range are observed in a graduated fashion among subclinical samples. Inhibitory control processes were also examined in the incarcerated group using the inhibitory N2 and anteriorized P3 as indices of inhibitory processes evident in correctly withholding prepotent response tendencies on a Go-NoGo task. Despite the common assumption that poor inhibitory control is a central aspect of psychopathy, there was no sign that those at higher levels of psychopathy showed any inhibitory control problems and they produced a robust NoGo N2 and P3. In fact, there were signs that the incarcerated offenders who were low on psychopathy were more likely to produce diminished inhibitory-related components. Finally, years of controversy regarding attention allocation deficits in psychopathy was addressed by collecting standard P3 components during a traditional visual oddball task in the university sample. Behavioural response and P3 amplitudes were unrelated to psychopathy. However, consistent with data from incarcerated samples, higher scores on psychopathy were associated with larger amplitude P2 and N5 responses to target relative to nontarget stimuli, again suggesting some continuity with respect to a distinct, although not necessarily deficient, attentional style at subclinical levels of psychopathy. In general, across these four data sets, the only clear evidence of impaired processing involved a reduced error-monitoring response during the face-flanker task when emotional stimuli formed the basis of the required discrimination and this reduced response was found to vary with the degree of psychopathy even within a subclinical range. These findings support a model of psychopathy involving limbic and paralimbic structures rather than a general reduction in neural function affecting error monitoring, attention allocation and response control.

In this research, an autonomous vehicle function management methodology is studied. In accordance with the traffic situation, the decision making level chooses the optimal function that guarantees safety and minimizes fuel consumption while the control level is implemented via neuromorphic strategy based on the brain limbic system. To realize the decision making strategy, the Analytic Hierarchy Process (AHP) is used by considering driving safety, driving speed, and fuel efficiency as the objectives. According to the traffic situation and predefined driving mode, Lane Change Maneuver (LCM) and Adaptive Cruise Control (ACC) are chosen as the alternative functions in the AHP framework. The adaptive AHP is utilized to cope with dynamically changing traffic environment. The proposed adaptive AHP algorithm provides an optimal relative importance matrix that is essential to make decisions under a varying traffic situation and driving modes. The simulation results show that proposed autonomous vehicle function management structure produces optimal decisions that satisfy the driving preference. The stability of BLS based control is also investigated via Cell-to-Cell Mapping. In this research, autonomous vehicle functions such as Lane change maneuver and Adaptive cruise control are developed by means of BLS based control. The simulation results considered various traffic situations that an autonomous vehicle can encounter. To demonstrate the suggested control method Cell-to-Cell Mapping is utilized. Subsequently, the autonomous vehicle function management strategy is developed by Applying AHP and an adaptive AHP strategy is developed to cope with various traffic situations and driving modes. The suggested method is verified numerical simulations.

No description available.

This research project investigates the long-term consequences of perinatal exposure to high-fat (HF) on the mesocorticolimbic dopamine (DA) system. Adult offspring of mothers fed a HF diet (30% fat, compared to 5% in control mothers (C)) during the last week of gestation and throughout lactation displayed decreased locomotion in response to an acute amphetamine challenge and decreased behavioral sensitization to repeated amphetamine compared to C animals. These behavioral effects were accompanied by small increases in tyrosine hydroxylase expression in the ventral tegmental area and significant increases in DA and DOPAC content in the NAc, suggesting an elevated DA tone in this target field. In the NAc, there were no significant changes in D1, D2 receptors or DA transporter (DAT) levels between diet groups. The behavioural and biochemical data were collected in adulthood, long after the termination of the diet suggesting that a HF perinatal diet is inducing permanent changes within the DA system and might contribute to the development of metabolic disturbances.

Thesis (M.Sc.). / Written for the Dept. of Neurology and Neurosurgery. Title from title page of PDF (viewed 2008/12/07). Includes bibliographical references.

Thesis (M.Sc.) - Carleton University, 2005. / Includes bibliographical references (p. 110-116). Also available in electronic format on the Internet.