Made available in DSpace on 2014-12-17T15:32:17Z (GMT). No. of bitstreams: 1 AndreaFS.pdf: 584148 bytes, checksum: 1823dffba43267f037cb07f5493ee540 (MD5) Previous issue date: 2004-12-20 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Regarding the morbidity potential of oral complications in patients with leukemia, it evaluated the cl?nical and microbiologic changes of oral mucosal in children with LLA, with age range of O to 15 years old, undergone the chemotherapy antineoplastic and for the use prophylactic of chlorhexidine gluconate 0,12% during ten days, that was utilized in each chemotherapy treatment stage. The collect for rnicrobiological study was obtained preferentiality in intensification stage at the end prophylatic treatment. The study grouup had 20 children, where it observed clinically decrease in frequency of mucositis, with 8 cases (40%) only. In microbiological examination observed one reduced incidence of pathogenic microorganisms with Staphylococcus coagulase- negative (40%), Klebsiella pneumoniae (5%), Escherichia coZi enteropathogenic (15%), Stenotrophomonas maltophilia (5%) e Candida albicans (35%). The findings obtained in the present trial suggest that the use of chlorhexidine gluconate 0,12% can be responsible for incidence reduced of mucositis, but it wasn t possible to make correlation between isolated pathogenic microorganisms and mucositis development / Considerando o potencial de morbidade das complica??es orais em pacientes com leucemia, procurou-se avaliar as altera??es clinicas e microbiol?gicas da mucosa, em crian?as com LLA. na faixa et?ria de O a 15 OOos, submetidas a quimioterapia antineopl?sica e ao uso profil?tico do gluconato de clorexidina a 0,12%, durante dez dias, o qual era administrado em todas as fases do tratamento quimioter?pico. A coleta para o estudo microbiol?gico foi obtida, preferencialmente, na fase de intensifica??o, ao t?rmino do tratamento profil?tico. A amostra foi constituida por 20 crian?as, na qual evidenciou-se em nivel clinico, uma freq??ncia reduzida de mucosite, com 8 ocorr?ncias (40%) apenas. No exame microbiol?gico, constatou-se a presen?a de reduzido n?mero de microrganismos patog?nicos, como Staphylococcus coagulase-negativo (40%), Klebsiella pneumoniae (5%), Escherichia coli-enteropatog?nica (15%), Stenotrophomonas maltophilia (5%) e Candida albicans (35%). Diante dos resultados, sugeriu-se que o uso do referido antiss?ptico contribuiu para a reduzida ocorr?ncia de mucosite, no entanto, n?o foi possivel estabelecer correla??o entre os microrganimos isolados e o desenvolvimento da mucosite