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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Predictors of changes in health-related quality of life during chemotherapy in an advanced non-small cell lung cancer patient population

Shallwani, Shirin Mehdi January 2009 (has links)
1 volume

What do newly diagnosed patients have to say regarding their preparation and ongoing needs during the experience of chemotherapy?

Palmer, April. January 2009 (has links)
Thesis (M.S.)--California State University, Chico. / Includes abstract. "Located in the Chico Digital Repository." Includes bibliographical references (p. 35-38).

Studies toward the synthesis of 3,6-bis-(5-chloro-2-piperidyl)-2, 5-piperazinedione

Moreland, Margaret. January 1979 (has links)
The naturally occurring compound 3,6-bis-(5-chloro-2-piperidyl)-2,5-piperazinedione (1) is a promising new antitumor drug. The mechanisms of action of antitumor alkylating agents, particularly the nitrogen mustards and sesquiterpene lactones, suggest possible modes of antitumor activity of compound 1. A possible synthetic scheme for compound 1 is developed by consideration of methods of synthesis of piperidines, (alpha)-substituted-(alpha),(beta)-unsaturated esters, and (beta)-amino alcohols. / A synthesis of (alpha)-chloro-(alpha),(beta)-unsaturated esters from carbonyl compounds and t-butyl (alpha)-chloro-(alpha)-trimethylsilyl acetate is developed. Oxyamination of the terminal double bond of t-butyl 2-chloro-2,6-heptadienoate occurs by epoxidation and reaction with an amine or azide ion and by osmium tetroxide catalyzed reaction with Chloramine-T. The piperidine ring is formed by an internal Michael raction of t-butyl 2-chloro-6-t-butyldimethylsilyloxy-7-tosylamino-2-heptenoate. The amino acid (1-tosyl-5-hydroxy-2-piperidyl) glycine is synthesized and found to be unstable to acidic esterification conditions. / Strategies for overcoming the problems encountered in the synthesis are discussed.

Studies toward the synthesis of 3,6-bis-(5-chloro-2-piperidyl)-2, 5-piperazinedione

Moreland, Margaret. January 1979 (has links)
No description available.

Azoreductases in cancer therapy

Sims, Margaret Alison January 1994 (has links)
No description available.

Protentiation of methotrexate cytotoxicity by indomethacin

Hollingsworth, Simon John January 1993 (has links)
No description available.

The effects of sequence selective antitumour antibiotics on DNA structure

Waterloh, Kerstin January 1991 (has links)
No description available.

A study of nephrotoxicity caused by cytotoxic drugs in children with cancer

Skinner, Roderick January 1994 (has links)
No description available.

The clinical and cellular pharmacology of carboplatin in relation to toxicity and response in epithelial ovarian cancer

Aswad, Saad Ghazal January 1994 (has links)
No description available.

The metabolism and potential toxicity mechanisms of thiotepa

Hoefer, Constance C. January 1995 (has links)
No description available.

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