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Die außergewöhnliche Diversität der Proteolipide in Archaea multimere und monomere Rotoren mit sechs bis dreizehn Ionenbindestellen in A1AO-ATPasen /Weidner, Claudia. Unknown Date (has links) (PDF)
Universiẗat, Diss., 2003--München.
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Dissecting class a scavenger receptor mediated cell adhesion and lipoprotein internalizationKosswig, Ninetta. Unknown Date (has links) (PDF)
University, Diss., 2003--Bonn.
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Der Einfluss akuter Alkoholbelastung auf die Lipoproteine und Triglyceride im Blutplasma des KaninchensZiegner, Elke, January 1983 (has links)
Thesis (doctoral)--Kiel, 1983.
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Modulation inflammatorischer Atherosklerosemarker durch Peroxisome proliferator-activated receptor-alpha (PPARalpha)-aktivierendes FenofibratGmelin, Katrin Anaka. January 2006 (has links)
Ulm, Univ. Diss., 2006.
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2-Desoxy-2-amino-phospholipidderivate als Inhibitoren der Platelet-activating factor Acetylhydrolase sowie Untersuchungen zur Wirkung von modifizierten (Lipo)-Proteinen auf P388D 1 Makrophagen und humane Endothelzellen /Fyrnys, Beatrix. January 1995 (has links)
Heidelberg, Universiẗat, Diss. : 1995.
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Lipoprotein particles associate with lipid-linked proteins and are required for long-range Wingless and Hedgehog signaling / Lipoprotein-Partikel assoziieren mit lipid-modifizierten proteinen und sind notwendig zur Wingless-und Hedgehog Signaltransduktion über grosse Distanzen.Panakova, Daniela 21 June 2005 (has links) (PDF)
Morphogens of the Wnt and Hedgehog families are secreted signaling molecules that coordinate growth and patterning of many different tissues. Both, Wingless and Hedgehog spread across long distances in developing wing of Drosophila melanogaster. However, both proteins are covalently modified with lipid moieties. The mechanisms that allow long-range movement of such hydrophobic molecules are unclear. Like Wingles and Hedgehog, glycosylphosphatidylinositol (gpi)-linked proteins also transfer between cells with their lipid anchor intact. It has been speculated that gpi-linked proteins and lipid-linked morphogens travel together on a membranous particle, which was termed an argosome. As yet however, no functional link between argosome production and dispersal of lipid-linked proteins has been established. The topic of this thesis is to understand the cell biological nature of the argosome and thus contribute to understanding of morphogen gradient formation. To address the question of argosome biosynthesis, at least two models have been proposed. One possibility is that argosomes are membranous exovesicles with a complete membrane bilayer. Alternatively, argosomes might resemble lipoprotein particles that comprise on of a family of apolipoproteins scaffolded around a phospholipid monolayer that surrounds a core of esterified cholesterol and triglyceride. Lipid-modified proteins of the exoplasmic face of the membrane (like GFPgpi, Wingless or Hedgehog) might fit well into the outer phospholipid monolayer of such a particle. Here, I utilize biochemical fractionation to determine the sort of particle that lipid-linked proteins associate with. I show that Wingless, Hedgehog and gpi-linked proteins bind Drosophila lipoprotein particles in vitro, and colocalize with them in wing imaginal discs. Next, I use genetic means to address the functional importance of this association. I demonstrate that reducing Lipophorin levels in Drosophila larvae perturbs long-range but not shor-range Wingless and Hedgehog signaling, and increases the sequestration of Hedgehog by Patched. I propose that Lipophorin particles are vehicles for the long-range movement of lipid-linked morphogens and gpi-linked proteins.
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Lipoprotein particles associate with lipid-linked proteins and are required for long-range Wingless and Hedgehog signalingPanakova, Daniela 01 July 2005 (has links)
Morphogens of the Wnt and Hedgehog families are secreted signaling molecules that coordinate growth and patterning of many different tissues. Both, Wingless and Hedgehog spread across long distances in developing wing of Drosophila melanogaster. However, both proteins are covalently modified with lipid moieties. The mechanisms that allow long-range movement of such hydrophobic molecules are unclear. Like Wingles and Hedgehog, glycosylphosphatidylinositol (gpi)-linked proteins also transfer between cells with their lipid anchor intact. It has been speculated that gpi-linked proteins and lipid-linked morphogens travel together on a membranous particle, which was termed an argosome. As yet however, no functional link between argosome production and dispersal of lipid-linked proteins has been established. The topic of this thesis is to understand the cell biological nature of the argosome and thus contribute to understanding of morphogen gradient formation. To address the question of argosome biosynthesis, at least two models have been proposed. One possibility is that argosomes are membranous exovesicles with a complete membrane bilayer. Alternatively, argosomes might resemble lipoprotein particles that comprise on of a family of apolipoproteins scaffolded around a phospholipid monolayer that surrounds a core of esterified cholesterol and triglyceride. Lipid-modified proteins of the exoplasmic face of the membrane (like GFPgpi, Wingless or Hedgehog) might fit well into the outer phospholipid monolayer of such a particle. Here, I utilize biochemical fractionation to determine the sort of particle that lipid-linked proteins associate with. I show that Wingless, Hedgehog and gpi-linked proteins bind Drosophila lipoprotein particles in vitro, and colocalize with them in wing imaginal discs. Next, I use genetic means to address the functional importance of this association. I demonstrate that reducing Lipophorin levels in Drosophila larvae perturbs long-range but not shor-range Wingless and Hedgehog signaling, and increases the sequestration of Hedgehog by Patched. I propose that Lipophorin particles are vehicles for the long-range movement of lipid-linked morphogens and gpi-linked proteins.
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