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ABSTRACT The diploma thesis called "Verification of efficiency and utilization of oilseed presses" is focused on the issue of oil pressing with emphasis on process efficiency and oil yield. A measurement was carried out at the Institute of Horticultural Engineering, the purpose of which was to verify the screw press of a small capacity UNO FM 3 F of Farmet, Czech Republic in the pressing of grape seed oil. The experimental measurements were carried out in 2018-2019 for seed samples provided by Agropol Mikulov, which were separated from the marc. The results of the work are divided into two main parts – Cold oil pressing and Soxhlet oil extraction and Economic aspects of wine production lines designed for seed processing and oil production. The seeds were compressed at 20, 40, 60, 80 and 100 rpm. The results confirmed that with increasing speed the pressing time was reduced. At higher speeds during compression, the amount of sediment increased. While pressing from 20 to 80 rpm, the oil yield decreased from 9.87 % to 9.67 % while the pressing capacity increased from 0.86 liter/hour to 2.17 liter/hour. It was no longer possible to press at speed 100 rpm, the machine was too overloaded. The Soxhlet extraction apparatus with hexane as solvent was used to determine the total oil content. Seed oiliness was 12.85 %. The market value of cold pressed oil from grapevine seeds, used in gastronomy or as a massage product, is 990-1100 CZK / liter. With an average crude oil yield of 8 %, from 1 ton of seeds, 80 liters of oil can be pressed, which represents the currently expected yield of 80-88 thousand. CZK. The results of the economic evaluation show that with all the costs involved in the oil production, including the investment costs for the production line, the return on investment is 3,23 years. From the results of the economic evaluation of the experiment at 9,8 %, from 1 ton of seeds the expected yield of 98 l of oil is 97 020 - 107 800 thous. CZK. The return on investment period was 1,92 years.

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1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Viktoria Kousoulidou Title of Thesis: Determination of the compressibility of excipients used for formulation of tablets with theophylline The current thesis is focused on the compressibility properties of five powders used in tablet formulation: Comprecel, Spherolac, DI-CAFOS D160, DI-CAFOS A150 as excipients and Theophylline as the active substance. The particle size, moisture content, bulk density and flowability of the powders are determined. The powders are compressed and the results are evaluated by means of the parameters of the compaction equation and the force-displacement method (compression under 5, 10, 15 kN). Then, the crushing strength of tablets prepared from each powder by the force-displacement method is measured. The average values of the crushing strength are used to calculate the tensile strength of the tablets. Best compressibility is found in Comprecel and Theophylline with tensile strength values of 1.31 MPa under 5 kN, 3.31 MPa under 10 kN, 4.75 MPa under 15 kN and 1.02 MPa under 5 kN, 2.27 MPa under 10 kN, 3.09 MPa under 15 kN, respectively.

The aim of dissertation was to evaluate physico-mechanical characteristics of pneumatic (membrane) press depending on pressing efficiency. As the result of economic evaluation was to determine the financial cost which occurs during pressing proces for 1 liter of juice, as well as make this analysis for different pressures.

This thesis describes methods of work and structural variants of wine presses used in modern wineries in detail. It summarizes strengths and weaknesses of technological solutions. The practical part of the thesis deals with the evaluation of two presses, each of which is based on a different principle. The effects of pressing were observed during the processing of three grape varieties -- Sauvignon, Chardonnay and Zweigeltrebe -- in 2011, 2012 and 2013. The amount of pressure, processing, most gain and productivity were assessed. The cost of processing one hectolitre of the product was fixed for both systems.

The process of wood plasticization and densification has been known for decades. It is used for improvement of mechanical properties of low density wood. The objective of this study is to compare two different methods of wood plasticization. Specimens made of European beech wood (Fagus sylvatica) were plasticized by hot steam or gaseous ammonia and then compressed in tangential direction. Stress-strain behaviour during compression was evaluated. In this study influence of growth ring angle on densification process was also investigated. Gaseous ammonia at a pressure of 0.2 MPa was less efficient than hot steam. The best plasticizing effect was reached by combining these two methods. A growth ring angle of 15° from direction of compression (almost tangential) was evaluated as the best for densification of European beech wood.

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Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical technology Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Kateřina Vávrová Title of Thesis: Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and microcrystalline cellulose The aim of this thesis was the dissolution testing of tablets containing theophylline, the mixture of two dicalcium phosphate types and microcrystalline cellulose. The influence of tablet composition on the dissolution profiles was evaluated. The tablets were prepared from the mixtures containing microcrystalline cellulose, dicalcium phosphate anhydrous and dihydrate. These substances were used as fillers. Prepared mixtures contained theophylline as a model active ingredient and magnesium stearate as lubricant. Afterwards, the dissolution tests were done. For these tests, the basket method was utilized. As a dissolution medium the 0,1M hydrochloric acid solution was used. From the results of this experiment we concluded that we can influence the total amount of released theophylline and the speed of its release by the different ratio of microcrystalline cellulose and one of dicalcium phosphate types. The fastest theophylline dissolution was in tablets with high...