The respiratory system is attentive, adaptive, learns and has memory. The respiratory system remembers repeated respiratory challenges to fine tune its motor activity by modulating neuronal synaptic strength. This phenomenon, respiratory long term facilitation (LTF), functions to strengthen the ability of respiratory motor neurons to enhance contraction of breathing muscles. LTF could serve as a protective mechanism against obstructive sleep apnea, a disease characterized by the collapse of upper airways, by restoring upper airway patency. LTF can be induced through modulation of vagal afferent feedback via repeated apneas. Here, we used reverse microdialysis, electrophysiology, neuropharmacology, and histology to determine if the nucleus of the solitary tract (NTS), a brain region exclusively receiving vagal afferents, is the origin of the neural circuit responsible for apnea-induced plasticity. My work shows bilateral injection of 5% lidocaine into the NTS prevented LTF. We conclude the NTS is required for triggering apnea-induced LTF.

Typescript. / Thesis (D.P.H.)--University of Hawaii at Manoa, 1987. / Bibliography: leaves 174-182. / xvii, 182 leaves, bound ill. 29 cm

Farmers will supply the raw ingredients for the emerging cellulosic ethanol industry. The long-term relationship between a farmer and a processing firm is expected to be contractual. A processing firm has an incentive to sign long-term contracts to ensure a cost-efficient level of raw ingredient supply. However, farmers generally prefer to operate with either no contract or a short-term contract in order to maintain options for adjustments in future acreage allocations due to changes in relative prices. Of interest in this research is to understand the incentives of farmers and calculating the efficient level of the “inflexibility premium”, which a processing firm must provide to a farmer when a long term contract is signed. A stochastic dynamic programming model is solved and with the help of Microsoft Excel numerically evaluated to illustrate the marginal inflexibility premium is increasing with contract length and the level of price variability, and is decreasing with the size of acreage adjustment costs.

Long-term residential care (LTRC) is a complex sociopolitical milieu where people from diverse backgrounds come to live and work together. In recent years health care restructuring has resulted in the closure of facilities; health care policy has narrowed the population that accesses LTRC so that only those who are the most medically and socially complex are admitted; and there has been a transformation of the work force, a workforce that is mainly comprised of Women of Colour and is among the lowest paid in health care. The purpose of this study was to critically examine the organization of care in LTRC within this context. The theoretical perspective guiding the study was informed by postcolonialism, postcolonial feminism, intersectionalities, and Foucaudian epistemology. The method of inquiry for the study was critical ethnography, which allowed for critical analysis of `taken for granted' assumptions in the organization of care. Over a period of ten months, I was immersed in two LTRC facilities in the Lower Mainland of British Columbia. Field work consisted of approximately 218 hours of participant observation. I conducted 51 interviews with administrators, family members, residents, and staff. I reviewed relevant provincial policies and facility-based policies and procedures. I also collected quantitative data related to resident transitions in the health care system (for example, admissions, discharges, and hospital admissions), and staffing levels. Findings from this study were discussed in three key themes. First, a systematic decommissioning of citizenship occurred for residents and staff in this setting. Second, the impact of health care restructuring over the past decade had important consequences for relationships between residents, family, and staff. Third, relational care took place in `stolen' moments that occurred despite heavy workloads. All of these themes were underscored by intra-gender oppression, relations of power, and influenced by discourses of ageism and corporatism, which ultimately played out in day to day interactions between those who live and work there. Recommendations from this study included: addressing the entrenched hierarchies in nursing, further examination of the public-private funding model in LTRC, and the introduction of an independent ombudsperson to ensure consistent, high quality care across the LTRC sector.

GABAergic interneurons in the basolateral complex (BLC) of the amygdala are a part of the emotional-learning circuitry of the brain and receive excitatory inputs from all sensory modalities via cortex and thalamus. Although the BLC, which is made up of the lateral amygdala (LA), basal amygdala (BA) and accessory basal nucleus, is under the influence of a strong inhibition brought about by local interneurons, little is known about the diversity, characteristics and functioning of these interneurons. In this study, I have characterised the BLC interneuron population using a transgenic mouse model in which enhanced green fluorescent protein has been tagged to the GAD67 promoter. This promoter is specifically expressed in all GABAergic interneurons, enabling us to visualise interneurons under UV light. Whole-cell recordings were made from GAD67 interneurons in the BLA to study their membrane and synaptic properties. On the basis of their firing properties, interneurons in the BLC were classified into six distinct groups. The calcium-binding proteins calbindin, calretinin and parvalbumin were found to be expressed differently in the LA and BA interneurons, with the majority of the interneurons in the LA expressing calretinin, whereas those in the BA mostly expressed parvalbumin. We also found diversity in the expression of postsynaptic glutamate receptors in the BLC. Long-term potentiation induced at the interneurons was specific to the cortical inputs in the LA. LTP was expressed only in interneurons that either lacked NMDA receptors or had NMDA receptors with fast decay kinetics. This form of LTP was mediated by calcium-permeable AMPA receptors and required a postsynaptic calcium rise for its induction This study shows that the interneurons in the BLC are a heterogenous population with respect to the expression of calcium-binding proteins, axonal morphology, synaptic and membrane properties. This heterogeneity in interneuron population may be essential for the specialised roles various types of interneurons play in the functioning of the amygdala and in emotional learning.

Satellite-based navigation systems make it possible to determine the relative positions of points on the earth with centimetre or even millimetre level accuracy over baselines of up to several thousand kilometres. The highest possible accuracy can only be achieved if the carrier phase integer ambiguities can be resolved. In order to resolve the L1 and L2 integer ambiguities over long GPS baselines, the double difference residual ionospheric errors must be estimated for every satellite, every epoch. The resulting number of parameters is usually too large for estimation using ordinary least squares to be practical due to the time or computing resources needed for the processing. The technique currently used to efficiently estimate the parameters is known as pre-elimination. Pre-elimination divides the unknowns into parameters of interest (the coordinates and ambiguities) and nuisance parameters (the ionospheric path delays). The nuisance parameters are treated as stochastic variables and modelled as process noise, avoiding the need for them to be explicitly estimated. Whilst this approach is highly efficient, it makes assumptions about the stochastic behaviour of the residual ionospheric error that are not necessarily valid. The effectiveness of preelimination can be increased through the use of a deterministic model of the ionosphere. It is the hypothesis of this research that the ionospheric error can be more effectively estimated than is possible with pre-elimination, leading to more reliable ambiguity resolution for long baseline precise positioning. (For complete abstract open document)

This thesis examines the impact of announcements of syndicated loans on the share prices of borrowing firms. I use a sample of 5,465 loan observations reported in the International Financing Review Platinum database to study this impact. Event study methodology is used. My overall results show significantly positive wealth effects on the borrowing firms. However, when I partition my data set into revolving credit agreements, term loans and hybrid loans, I find that the results are driven primarily by revolving credit agreements. I also observe that the size of the event window plays an important role in identifying the wealth effects for the borrowers. A five-day event window (-2, +2) shows share price response to revolving credit announcements to be significantly positive. A three-day event window (-1, +1) reveals that announcements are statistically positive for revolving credit agreements and statistically negative for term loan announcements. My results are consistent with previous studies in this area. I also distinguish between financial press announcements and information provider (IFR) announcements to cater for the potential for reporting bias. I find that both the IFR and financial press announcements are significant for the five-day window, but only the financial press results are significant for the three-day window. My study is unique in that I differentiate the impact of different sources of information on the market reaction to borrower share price. In addition to the examination of the wealth effect, I also use the structure of the loans to examine the uniqueness of bank loans and their ability to provide financial slack. Specifically, I examine whether revolving credit loans or term loans or hybrid loans make bank loans unique and their ability to provide financial slack. I observe that out of the three structures of bank loan, only revolving credit loans allow the borrower to more precisely match the funds acquired with the firm’s investment needs and to market time by borrowing at times when financing costs are attractive. Revolving credit loans are positively valued by the market both initially and over the longer term. Bank loans reduce information asymmetry, but the renegotiation characteristics of revolving credit loans allow borrowers to exploit changes in the interest rate environment, thus providing support for the market timing theory of capital structure. In contrast to puzzling results of previous studies, I present evidence of long-term positive performance following bank loans.

Thesis (M.S.)--University of North Carolina at Greensboro, 2007. / Title from PDF t.p. (viewed Mar. 11, 2008). Directed by Jennifer L. Etnier; submitted to the School of Health and Human Performance. Includes bibliographical references (p. 40-43).

Thesis (M.Ed.)--Cleveland State University, 2007. / Abstract. Title from PDF t.p. (viewed on May 8, 2008). Includes bibliographical references (p. 60-62). Available online via the OhioLINK ETD Center. Also available in print.

Thesis (Ph. D.)--School of Nursing. University of Missouri--Kansas City, 2007. / "A dissertation in nursing." Advisor: Katharine Smith. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Jan. 2, 2008. Includes bibliographical references (leaves 155-168). Online version of the print edition.