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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Mechanical response of the porcine cervical spine to acute and repetitive anterior-posterior shear

Howarth, Samuel 07 January 2011 (has links)
Approximately 80% of the population will experience low-back pain within their lifetime. Significant research efforts have focused on compressive loading as an injury mechanism that could lead to low-back pain and injury. However, the influence of shear loading, and its relationship to vertebral tissue tolerances as well as modulating factors for these tolerances have not been studied as extensively. The primary objective of this thesis was to produce a series of investigations that begin to determine the roles of different modulating factors such as posture, compression, bone density, bone morphology, and repetitive load magnitude on measured vertebral joint shear failure tolerances. The thesis comprises four independent studies using in vitro mechanical testing, imaging modalities, and finite element modeling. Each of the in vitro studies within this thesis used a validated porcine cervical model as a surrogate for the human lumbar spine. The first study employed in vitro mechanical testing to investigate the combined roles of flexion/extension postural deviation and compressive load on the measured ultimate shear failure tolerances. Peripheral quantitative computed tomography scans of the pars interarticularis and measurements of vertebral bone morphology were used in the second investigation along with in vitro mechanical testing to identify the morphological characteristics that can be used to predict ultimate shear failure tolerances. The influence of sub-maximal shear load magnitude on the cumulative shear load and number of loading cycles sustained prior to failure were investigated with in vitro mechanical testing in the third study. Finally, a finite element model of the porcine C3-C4 functional spinal unit was used to investigate the plausibility of hypotheses, developed from previous research and the findings of the first investigation for this thesis, surrounding alterations in measured ultimate shear failure tolerances as a function of changes in facet interaction. Results from the first investigation showed that there was no statistically significant interaction between postural deviation and compressive force on ultimate shear failure tolerance. However, ultimate shear failure tolerance was reduced (compared to neutral) by 13.2% with flexed postures, and increased (compared to neutral) by 12.8% with extended postures. Each 15% increment (up to a maximum of 60% of predicted compressive failure tolerance) in compressive force was met with an average 11.1% increase in ultimate shear failure tolerance. It was hypothesized that alterations in flexion/extension posture and/or compressive force altered the location for the force centroid of facet contact. These changes in the location of facet contact were hypothesized to produce subsequent changes in the bending moment at the pars interarticularis that altered the measured ultimate shear failure tolerance. The three leading factors for calculating of measured ultimate shear failure tolerance were the pars interarticularis length for the cranial vertebra, the average facet angle measured in the transverse plane, and cortical bone area through the pars interarticularis. A bi-variate linear regression model that used the cranial vertebra’s pars interarticularis length and average facet angle as inputs was developed to nondestructively calculate ultimate shear failure tolerances of the porcine cervical spine. Longer pars interarticularis lengths and facets oriented closer to the sagittal plane were associated with higher measured ultimate shear failure tolerances. Fractures observed in this investigation were similar to those reported for studies performed with human specimens and also similar to reported spondylolitic fractures associated with shear loading in humans. This provided additional evidence that the porcine cervical spine is a suitable surrogate in vitro model for studying human lumbar spine mechanics. Altered sub-maximal shear load magnitude create a non-linear decrease in both the number of cycles and the cumulative shear load sustained prior to failure. These findings suggested that estimates of cumulative shear load should assign greater importance to higher instantaneous shear loads. This was due to an increased injury potential at higher instantaneous shear loads. Cumulative load sustained prior to failure was used to develop a tissue-based weighting factor equation that would apply nonlinearly increased weight to higher shear load magnitudes in estimates of cumulative shear load. A finite element model of the porcine C3-C4 functional spinal unit was created, and simulations were performed using similar boundary conditions as the comparable in vitro tests, to assess the plausibility of the moment arm hypothesis offered within the first investigation of this thesis. Moment arm length between the force centroid of facet contact and the location of peak stress within the pars interarticularis was increased for flexed postures and decreased for extended postures. Alterations in moment arm length were larger for postural deviation than compressive force, suggesting a secondary mechanism to explain the observed increase in shear failure tolerance with higher compressive loads from the first investigation. One such possibility was the increase in the number of contacting nodes with higher compressive forces. Alterations in moment arm length were able to explain 50% of the variance in measured ultimate shear failure tolerances from the first study. Thus, the finite element model was successful in demonstrating the plausibility of moment arm length between the force centroid of facet contact and the pars interarticularis as a modulator of measured ultimate shear failure tolerance. This thesis has developed the basis for understanding how failure of the vertebral joint exposed to shear loading can be modulated. In particular, this thesis has developed novel equations to predict the ultimate shear failure tolerance measured during in vitro testing, and to determine appropriate weighting factors for sub-maximal shear forces in calculations of cumulative shear load. Evidence presented within this thesis also provides support for the long-standing moment arm hypothesis for modulation of shear injury potential.
2

Mechanical response of the porcine cervical spine to acute and repetitive anterior-posterior shear

Howarth, Samuel 07 January 2011 (has links)
Approximately 80% of the population will experience low-back pain within their lifetime. Significant research efforts have focused on compressive loading as an injury mechanism that could lead to low-back pain and injury. However, the influence of shear loading, and its relationship to vertebral tissue tolerances as well as modulating factors for these tolerances have not been studied as extensively. The primary objective of this thesis was to produce a series of investigations that begin to determine the roles of different modulating factors such as posture, compression, bone density, bone morphology, and repetitive load magnitude on measured vertebral joint shear failure tolerances. The thesis comprises four independent studies using in vitro mechanical testing, imaging modalities, and finite element modeling. Each of the in vitro studies within this thesis used a validated porcine cervical model as a surrogate for the human lumbar spine. The first study employed in vitro mechanical testing to investigate the combined roles of flexion/extension postural deviation and compressive load on the measured ultimate shear failure tolerances. Peripheral quantitative computed tomography scans of the pars interarticularis and measurements of vertebral bone morphology were used in the second investigation along with in vitro mechanical testing to identify the morphological characteristics that can be used to predict ultimate shear failure tolerances. The influence of sub-maximal shear load magnitude on the cumulative shear load and number of loading cycles sustained prior to failure were investigated with in vitro mechanical testing in the third study. Finally, a finite element model of the porcine C3-C4 functional spinal unit was used to investigate the plausibility of hypotheses, developed from previous research and the findings of the first investigation for this thesis, surrounding alterations in measured ultimate shear failure tolerances as a function of changes in facet interaction. Results from the first investigation showed that there was no statistically significant interaction between postural deviation and compressive force on ultimate shear failure tolerance. However, ultimate shear failure tolerance was reduced (compared to neutral) by 13.2% with flexed postures, and increased (compared to neutral) by 12.8% with extended postures. Each 15% increment (up to a maximum of 60% of predicted compressive failure tolerance) in compressive force was met with an average 11.1% increase in ultimate shear failure tolerance. It was hypothesized that alterations in flexion/extension posture and/or compressive force altered the location for the force centroid of facet contact. These changes in the location of facet contact were hypothesized to produce subsequent changes in the bending moment at the pars interarticularis that altered the measured ultimate shear failure tolerance. The three leading factors for calculating of measured ultimate shear failure tolerance were the pars interarticularis length for the cranial vertebra, the average facet angle measured in the transverse plane, and cortical bone area through the pars interarticularis. A bi-variate linear regression model that used the cranial vertebra’s pars interarticularis length and average facet angle as inputs was developed to nondestructively calculate ultimate shear failure tolerances of the porcine cervical spine. Longer pars interarticularis lengths and facets oriented closer to the sagittal plane were associated with higher measured ultimate shear failure tolerances. Fractures observed in this investigation were similar to those reported for studies performed with human specimens and also similar to reported spondylolitic fractures associated with shear loading in humans. This provided additional evidence that the porcine cervical spine is a suitable surrogate in vitro model for studying human lumbar spine mechanics. Altered sub-maximal shear load magnitude create a non-linear decrease in both the number of cycles and the cumulative shear load sustained prior to failure. These findings suggested that estimates of cumulative shear load should assign greater importance to higher instantaneous shear loads. This was due to an increased injury potential at higher instantaneous shear loads. Cumulative load sustained prior to failure was used to develop a tissue-based weighting factor equation that would apply nonlinearly increased weight to higher shear load magnitudes in estimates of cumulative shear load. A finite element model of the porcine C3-C4 functional spinal unit was created, and simulations were performed using similar boundary conditions as the comparable in vitro tests, to assess the plausibility of the moment arm hypothesis offered within the first investigation of this thesis. Moment arm length between the force centroid of facet contact and the location of peak stress within the pars interarticularis was increased for flexed postures and decreased for extended postures. Alterations in moment arm length were larger for postural deviation than compressive force, suggesting a secondary mechanism to explain the observed increase in shear failure tolerance with higher compressive loads from the first investigation. One such possibility was the increase in the number of contacting nodes with higher compressive forces. Alterations in moment arm length were able to explain 50% of the variance in measured ultimate shear failure tolerances from the first study. Thus, the finite element model was successful in demonstrating the plausibility of moment arm length between the force centroid of facet contact and the pars interarticularis as a modulator of measured ultimate shear failure tolerance. This thesis has developed the basis for understanding how failure of the vertebral joint exposed to shear loading can be modulated. In particular, this thesis has developed novel equations to predict the ultimate shear failure tolerance measured during in vitro testing, and to determine appropriate weighting factors for sub-maximal shear forces in calculations of cumulative shear load. Evidence presented within this thesis also provides support for the long-standing moment arm hypothesis for modulation of shear injury potential.

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