L-citrulline and malate are amino acids within the body that have the potential to affect muscular endurance during athletic performances. Purpose: This study intended to test the effectiveness of CM on muscular performance and fatigue during a lower body resistance protocol. Methods: Twelve trained males completed a lower body resistance training protocol for two sessions, one using CM (8.0g) and the other with placebo (PL), within a randomized, double blind, counterbalanced study. Results: CM supplementation increased repetitions in leg press, hack squat and leg extension. Blood lactate was significantly increased post-exercise compared to pre-exercise, but no significant difference was found between CM and placebo. In addition, no significant differences were found for systolic blood pressure, diastolic blood pressure, or HR between the CM and PL groups. Conclusion: These findings suggest CM attenuates muscular fatigue during a specific lower body exercise protocol.